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首页> 外文期刊>Chinese journal of digestive diseases >Survey of the genotype for S-mephenytoin hydroxylase in the Chinese Han population
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Survey of the genotype for S-mephenytoin hydroxylase in the Chinese Han population

机译：中国汉族人群S-苯甲酰羟化酶基因型调查

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OBJECTIVE: S-mephenytoin hydroxylase is a polymorphic cytochrome P450 (GYP) enzyme that catalyzes the metabolism of omeprazole, a proton-pump inhibitor, and some other drugs. The aim of this survey was to investigate the distribution of the genotype of S-mephenytoin hydroxylase in Chinese people.METHODS: One hundred and fifty-five unrelated healthy volunteers were selected and their blood samples were used for genotyping by PCR-restriction enzyme analysis. DNA from homozygous extensive metabolizers (EM) could be digested into two fragments, whereas poor metabolizers (PM) could not be digested and heterozygous EM could be partly digested.
机译：目的：S-美芬妥英羟化酶是一种多态性细胞色素P450（GYP）酶，能催化奥美拉唑，质子泵抑制剂和其他一些药物的代谢。本研究的目的是调查中国人群中S-甲氧苯妥因羟化酶基因型的分布。方法：选择一百五十五个无亲缘关系的健康志愿者，并通过PCR-限制性内切酶分析法对其血液样本进行基因分型。纯合的广泛代谢者（EM）的DNA可以被消化成两个片段，而弱代谢者（PM）不能被消化，杂合的EM可以被部分消化。

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