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首页> 外文期刊>Chinese journal of digestive diseases >Clinicopathologic characteristics of Chinese hereditary non-polyposis colorectal cancer
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Clinicopathologic characteristics of Chinese hereditary non-polyposis colorectal cancer

机译：中国遗传性非息肉性大肠癌的临床病理特征

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摘要

OBJECTIVE: The aim of the present study was to examine the clinicopathologic characteristics of Chinese patients with hereditary non-polyposis colorectal cancer (HNPCC) and those with suspected (atypical) HNPCC.METHODS: Personal and family cancer histories were obtained by reviewing the charts and interviewing the proband and participating relatives. Families were identified and classified into three groups by either the Amsterdam or Japanese criteria for HNPCC. Clinical characteristics including onset, localization, stage of colorectal cancer (CRC), tumor multiplicity, survival and mucinous histology were evaluated.RESULTS: Ninety-eight subjects comprising 92 CRC patients and six extracolonic cancer patients from 13 typical and 19 non-typical HNPCC kindreds were enrolled. There were 53 patients with CRC, one with both CRC and extracolonic cancer and five with extracolonic cancer in the typical HNPCC group, and in the atypical group there were 38 patients with CRC and one with extracolonic cancer. The average onset age of typical HNPCC and atypical HNPCC was 48 and 50 years, respectively, without statistical difference. There were no statistical differences in sex, pathological type, stage, site distribution of the tumor or survival between typical HNPCC and atypical HNPCC groups. There were 11.1% (6/54) metachronous CRC in the typical HNPCC group, and 7.9% (3/38) metachronous and 2.6% (1/38) synchronous CRC in the atypical HNPCC group.
机译：目的：本研究的目的是检查中国遗传性非息肉性结直肠癌（HNPCC）患者和疑似（非典型）HNPCC患者的临床病理特征。方法：通过回顾图表和资料，了解个人和家庭癌症的历史采访先证者和参与的亲戚。根据阿姆斯特丹或日本的HNPCC标准，确定了家庭并将其分为三类。结果包括：92名CRC患者和来自13个典型和19个非典型HNPCC亲属的6例结肠外癌患者，共计98名受试者，包括结直肠癌（CRC）的发作，定位，分期，肿瘤的多重性，生存率和黏液组织学。被录取了。典型的HNPCC组中有53例CRC患者，其中1例同时患有CRC和结肠外癌，另外5例患有结肠外癌，而在非典型组中，有38例CRC患者和1例患有结肠外癌。典型HNPCC和非典型HNPCC的平均发病年龄分别为48岁和50岁，无统计学差异。典型HNPCC组和非典型HNPCC组在性别，病理类型，分期，肿瘤部位分布或生存率方面无统计学差异。典型的HNPCC组中有11.1％（6/54）的同步性CRC，非典型HNPCC组中有7.9％（3/38）的同步性和2.6％（1/38）的同步性CRC。

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