Changes in somatostatin receptor expression of the pancreas and effectiveness of octreotide in rats with acute necrotizng pancreatitis

Jian Xin WU; Yao Zong YUAN; Jia Yu XU; Zong Qin XIA; Lan Feng QIN; Zheng Lin ZHENG

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Changes in somatostatin receptor expression of the pancreas and effectiveness of octreotide in rats with acute necrotizng pancreatitis

机译：急性坏死性胰腺炎大鼠胰腺生长抑素受体表达的变化和奥曲肽的有效性

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OBJECTIVE: To investigate changes in the expression of the somatostatin receptor (SSTR) of the pancreas and of pancreatic blood flow, and its relationship to the metabolism of eicosanoids in order to elucidate the effectiveness of octreotide, an analog of somatostatin, in acute necrotizing pancreatitis (ANP).METHODS: A model of ANP was induced in rats with injection of sodium taurocholate via the pancre-aticobiliary duct. The SSTR was detected using a radio-ligand binding assay (RBA) with ~125I-somatostatin-14, and the SSTR2 mRNA of the pancreas was analyzed using in situ hybridization. Pancreatic blood flow and the metabolites of eicosanoids were also determined.

机译：目的：研究胰腺生长激素释放抑制素受体（SSTR）的表达和胰腺血流的变化，及其与类花生酸代谢的关系，以阐明生长抑素类似物奥曲肽在急性坏死性胰腺炎中的有效性。方法：通过胰-胆管导管注射牛磺胆酸钠对大鼠产生ANP模型。使用带有〜125I-somatostatin-14的放射性配体结合测定（RBA）检测SSTR，并使用原位杂交分析胰腺的SSTR2 mRNA。还确定了胰腺的血流和类花生酸的代谢产物。

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来源
《Chinese journal of digestive diseases》 |2004年第1期|共5页
作者
Jian Xin WU; Yao Zong YUAN; Jia Yu XU; Zong Qin XIA; Lan Feng QIN; Zheng Lin ZHENG;
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正文语种 eng
中图分类医药、卫生;
关键词
acute pancreatitis; in situ hybridization; octreotide; radioligand binding assay (RBA); receptor; somatostatin;

机译：急性胰腺炎;原位杂交;奥曲肽;放射配体结合试验（RBA）;受体;生长抑素;

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1. Changes in somatostatin receptor expression of the pancreas and effectiveness of octreotide in rats with acute necrotizng pancreatitis [J] . Jian Xin WU, Yao Zong YUAN, Jia Yu XU, Chinese journal of digestive diseases . 2004,第1期

机译：急性坏死性胰腺炎大鼠胰腺生长抑素受体表达的变化和奥曲肽的有效性
2. Protective effect of the somatostatin analogue octreotide in ischemia/reperfusion-induced acute pancreatitis in rats. [J] . Hoffmann TF, Uhl E, Messmer K Pancreas . 1996,第3期

机译：生长抑素类似物奥曲肽对大鼠缺血/再灌注致急性胰腺炎的保护作用。
3. Effects of octreotide on lipid peroxidation in pancreas and plasma in acute hemorrhagic necrotizing pancreatitis in rats. [J] . Wenger FA, Kilian M, Jacobi CA, Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] . 2002,第3期

机译：奥曲肽对急性出血坏死性胰腺炎大鼠胰腺和血浆脂质过氧化的影响。
4. Effect of Huoxue Huayu (Promoting Blood Circulation for Removing Blood Stasis) Injection(HHI-Ⅰ) on the Expression of CD11b/CD18 in Lung and Pancreas with Severe Acute Pancreatitis(SAP) in Rats [C] . The Third international congress on TCM : Collection of papers . 2001

机译：活血化瘀活血注射液（HHI-Ⅰ）对重症急性胰腺炎（SAP）大鼠肺和胰腺CD11b / CD18表达的影响
5. MGLU2/3 Receptor Agonist LY379268 on ERK and CREB Protein Expression and Phosphorylation: Analysis of Acute and Chronic Treatment of Rats [D] . Burgos Aguilar, Carolina. 2019

机译：ERK和CREB蛋白表达和磷酸化的MGLU2 / 3受体激动剂LY379268：急性和慢性治疗大鼠的分析
6. Comparative studies on the expression of somatostatin receptor subtypes outcome of octreotide scintigraphy and response to octreotide treatment in patients with carcinoid tumours. [O] . O. Nilsson, L. KÃ¶lby, B. WÃ¤ngberg, 1998

机译：类癌肿瘤患者生长抑素受体亚型表达奥曲肽闪烁显像结果和对奥曲肽治疗反应的比较研究。
7. Comparative studies on the expression of somatostatin receptor subtypes, outcome of octreotide scintigraphy and response to octreotide treatment in patients with carcinoid tumours. [O] . Nilsson, O., KÃ¶lby, L., WÃ¤ngberg, B., 1998

机译：类癌肿瘤患者生长抑素受体亚型表达，奥曲肽闪烁显像结果和对奥曲肽治疗反应的比较研究。

Changes in somatostatin receptor expression of the pancreas and effectiveness of octreotide in rats with acute necrotizng pancreatitis

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