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首页> 外文期刊>Chinese journal of digestive diseases >Relationship between Helicobacter pylori infection and gastroesophageal reflux disease
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Relationship between Helicobacter pylori infection and gastroesophageal reflux disease

机译：幽门螺杆菌感染与胃食管反流病的关系

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摘要

Gastroesophageal reflux disease (GERD) is a common and costly disease in the community, and has a negative impact on quality of life.The major mechanisms associated with GERD include decreased pressure and increased frequency of spontaneous relaxation of the lower esophageal sphincter (LES) with normal or increased secretion of gastric acid. Helicobacter pylori infection, a recognized pathogen of gastritis, peptic ulcer disease and gastric cancer, may be involved in the pathogenesis of GERD, as any effect of H. pylori infection on the LES or local gastric acid secretion may lead to either the occurrence or disappearance of GERD. However, conflicting results have been obtained; some epidemiological and clinical studies have suggested a protective role of H. pylori infection in the development of GERD, whereas others have failed to confirm this role. The aim of this review is to provide current knowledge on the relationship between H. pylori infection and GERD.
机译：胃食管反流病（GERD）是社区常见且代价高昂的疾病，对生活质量产生负面影响。与GERD相关的主要机制包括降低食管下括约肌（LES）的压力和自发放松频率胃酸分泌正常或增加。幽门螺杆菌感染是公认的胃炎，消化性溃疡疾病和胃癌病原体，可能与GERD的发病有关，因为幽门螺杆菌感染对LES或胃酸局部分泌的任何影响都可能导致其发生或消失。 GERD。但是，已经获得了矛盾的结果。一些流行病学和临床研究表明幽门螺杆菌感染在GERD的发生中具有保护作用，而另一些则未能证实这一作用。这篇综述的目的是提供关于幽门螺杆菌感染与GERD之间关系的最新知识。

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