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18-crown-6-aminophenol isomer complexes studied by RPLC

机译：RPLC研究的18-冠-6-氨基苯酚异构体

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摘要

The reserved-phase liquid chromatography retention of aminophenol isomer was investigated over a concentration range of 18-crown-6 (c: 0 - 0.15 M) using a C18 as the stationary phase and a phosphate buffer pH 2 as the mobile phase. A theoretical treatment was developed to investigate the effect of the polyether on the equilibrium between the solutes with the C18 phase and the aqueous medium respectively. This was found to be adequate to accurately describe the isomer retention behavior when c varied. it was expected that the addition of 18-crown-6 was responsible for an increase in the solute affinity for the C18 stationary phase due to complex formation and blockage of the polar amino group of the solute. The thermodynamic parameter variations were calculated using van't Hoff plots. The enthalphy-entropy compensation was analyzed in relation to this retention model to confirm the influence of the modifier on the solute affinity towards the C18 phase. From the experimental data, the complexation and transfer constants for the different species were determined for the three isomers. This indicated that the hydroxyl group of the solute governed both the complexation and retention processes via hydrogen bonding and steric effects. [References: 38]
机译：使用C18作为固定相和磷酸盐缓冲液pH 2作为流动相，研究了18-crown-6（c：0-0.15 M）浓度范围内氨基酚异构体的保留相液相色谱保留。开发了一种理论方法以研究聚醚对分别具有C18相的溶质和水性介质之间平衡的影响。发现这足以精确地描述当c变化时的异构体保留行为。可以预料，由于络合物的形成和溶质极性氨基的封闭，增加了18-crown-6可以增加对C18固定相的溶质亲和力。使用van't Hoff图计算热力学参数变化。针对该保留模型分析了焓-熵补偿，以确认改性剂对溶质对C18相的亲和力的影响。根据实验数据，确定了三种异构体的不同物种的络合和转移常数。这表明溶质的羟基通过氢键和空间效应控制络合和保留过程。 [参考：38]

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