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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >Different therapeutic outcomes in experimental allergic encephalomyelitis dependant upon the mode of delivery of IL-10: A comparison of the effects of protei,adenoviral or retroviral IL-10 delivery into the central nervous system
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Different therapeutic outcomes in experimental allergic encephalomyelitis dependant upon the mode of delivery of IL-10: A comparison of the effects of protei,adenoviral or retroviral IL-10 delivery into the central nervous system

机译：实验性变应性脑脊髓炎的不同治疗结果取决于IL-10的递送方式：蛋白，腺病毒或逆转录病毒IL-10进入中枢神经系统的作用比较

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摘要

Experimental allergic encephalomyelitis (EAE) is a CNS autoimmune disease mediated by the action of CD4~ T cells, macro-phages, and proinflammatory cytokines. IL-lO is a cytokine shown to have many anti-inflammatory properties. Studies have shown both inhibition and exacerbation of EAE after systemic IL-lO protein administration. We have compared the inhibitory effect in EAE of 1110 gene delivery in the CNS. Fibroblasts transduced with retroviral vectors expressing IL-lO could inhibit EAE. This was not associated with a prevention of cellular recruitment but an alteration in their phenotype, notably an increase in the numbers of CD8~ T and B cells. In marked contrast, CNS delivery of adenovirus coding for mouse IL-b or IL-lO protein performed over a wide dose range failed to inhibit disease, despite producing similar or greater amounts of IL-lO protein. Thus the action of IL-10may differ depending on the local cytokine microenvironment produced by the gene-secreting cell types.
机译：实验性变应性脑脊髓炎（EAE）是由CD4〜T细胞，巨噬细胞和促炎细胞因子的作用介导的中枢神经系统自身免疫性疾病。 IL-10是显示出具有许多抗炎特性的细胞因子。研究表明，全身性IL-10蛋白给药后EAE的抑制和加剧。我们比较了中枢神经系统中1110基因传递对EAE的抑制作用。用表达IL-10的逆转录病毒载体转导的成纤维细胞可以抑制EAE。这与防止细胞募集无关，但与它们的表型改变有关，特别是CD8T和B细胞数目的增加。与之形成鲜明对比的是，尽管在宽剂量范围内进行了编码小鼠IL-1b或IL-10蛋白的编码腺病毒的CNS递送，但尽管产生了相似或更多量的IL-10蛋白也未能抑制疾病。因此，IL-10的作用可能取决于基因分泌细胞类型产生的局部细胞因子微环境。

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