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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >Oxidized Low-Density Lipoprotein Promotes Mature Dendritic Cell Transition from Differentiating Monocyte
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Oxidized Low-Density Lipoprotein Promotes Mature Dendritic Cell Transition from Differentiating Monocyte

机译：氧化的低密度脂蛋白促进成熟的树突状细胞分化的单核细胞过渡。

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Proinflammatory oxidized phospholipids anr generated during oxidative modification of low-density lipoproteins (LDL). The production of these proinflammatory oxidized phospholipids is controlled by secreted enzymes that circulate as proteins conplexed with LDL and high-density lipoprotein. During the acute phase response to tissue injury, profound changes occur in lipoprotein enzymatic composition that alter their anti-inflammatory function. Monocytes may encounter oxidized phospholipids in vivo during their differentiation to macrophages or dendritic cells (DC). In this study we show that the presence of oxidized LDL (oxLDL) at the first day of monocyte differentiation to DC in vitro yielded phenotypically atypical cells with some functional characteristics of mature DC. Addition of oxLDL during the late stage of monocyte differentiation gave rise directly to phenotypically mature DC with reduced uptake capacity, secreting IL-12 but not IL-10, and supporting both syngeneic and allogeneic T cell stimulation. In contrast to known mediators of DC activation, oxLDL did not trigger maturation of immature DC. An intriguing possibility is that a burst of oxidized phospholipids is an endogenous activation signal for the immune system, which is tightly controlled by lipoproteins during the acute phase response.
机译：低密度脂蛋白（LDL）氧化修饰过程中产生的促炎性氧化磷脂和。这些促炎性氧化磷脂的产生受分泌的酶控制，这些酶以与LDL和高密度脂蛋白复合的蛋白形式循环。在对组织损伤的急性期反应中，脂蛋白酶组成发生了深刻的变化，从而改变了它们的抗炎功能。单核细胞在分化为巨噬细胞或树突状细胞（DC）的过程中可能会在体内遇到氧化的磷脂。在这项研究中，我们表明在体外单核细胞分化为DC的第一天，氧化LDL（oxLDL）的存在会产生具有成熟DC某些功能特征的表型非典型细胞。在单核细胞分化的后期添加oxLDL，直接导致表型成熟的DC，其吸收能力降低，分泌IL-12，但不分泌IL-10，并支持同基因和同基因T细胞刺激。与已知的DC激活介质相反，oxLDL不会触发未成熟DC的成熟。一个有趣的可能性是，氧化磷脂的爆发是免疫系统的内源性激活信号，在急性期反应期间，脂蛋白严格控制着该信号。

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