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首页> 外文期刊>The Journal of Infectious Diseases >Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.
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Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.

机译：交叉反应性记忆CD8（+）T细胞以序列特异性方式改变了小鼠异源继发登革热病毒感染的免疫反应。

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摘要

Dengue virus is the causative agent of dengue fever and the more-severe dengue hemorrhagic fever (DHF). Human studies suggest that the increased risk of DHF during secondary infection is due to immunopathology partially mediated by cross-reactive memory T cells from the primary infection. To model T cell responses to sequential infections, we immunized mice with different sequences of dengue virus serotypes and measured the frequency of peptide-specific T cells after infection. The acute response after heterologous secondary infections was enhanced compared with the acute or memory response after primary infection. Also, the hierarchy of epitope-specific responses was influenced by the specific sequence of infection. Adoptive-transfer experiments showed that memory T cells responded preferentially to the secondary infection. These findings demonstrate that cross-reactive T cells from a primary infection alter the immune response during a heterologous secondary infection.
机译：登革热病毒是登革热和更严重的登革出血热（DHF）的病原体。人体研究表明，继发感染期间DHF风险增加是由于免疫病理部分由原发感染产生的交叉反应性记忆T细胞介导的。为了模拟T细胞对顺序感染的反应，我们用不同序列的登革热病毒血清型免疫小鼠，并测量感染后肽特异性T细胞的频率。与原发感染后的急性或记忆反应相比，异源继发感染后的急性反应得到了增强。同样，表位特异性反应的层次受到感染的特定顺序的影响。过继转移实验表明记忆T细胞对继发感染有优先反应。这些发现表明，来自原发感染的交叉反应性T细胞在异源继发感染期间改变了免疫反应。

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