Elevated Virus Loads of Kaposi's Sarcoma-Associated Human Herpesvirus 8 Predict Kaposi's Sarcoma Disease Progression, but Elevated Levels of Human Immunodeficiency Virus Type 1 Do Not.

Quinlivan EB; Zhang C; Stewart PW; Komoltri C; Davis MG; Wehbie RS

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Elevated Virus Loads of Kaposi's Sarcoma-Associated Human Herpesvirus 8 Predict Kaposi's Sarcoma Disease Progression, but Elevated Levels of Human Immunodeficiency Virus Type 1 Do Not.

机译：卡波西氏肉瘤相关人类疱疹病毒的病毒载量升高8预测卡波西氏肉瘤疾病的进展，但人类免疫缺陷病毒1型水平升高却没有。

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Kaposi's sarcoma-associated herpesvirus (KSHV) is found in Kaposi's sarcoma (KS), multicentric Castleman's disease, and primary effusion lymphomas. To prospectively evaluate KSHV load as a biomarker for KS clinical status and prognosis in a cohort of men with AIDS-related KS, 2 quantitative polymerase chain reaction (PCR) assays were developed and tested to determine KSHV peripheral blood mononuclear cell (PBMC) virus loads. Most patients (13/15) with good-prognosis KS had

机译：卡波西氏肉瘤相关疱疹病毒（KSHV）发现于卡波西氏肉瘤（KS），多中心Castleman病和原发渗出性淋巴瘤中。为了前瞻性地评估KSHV载量作为AIDS相关KS患者队列中KS临床状态和预后的生物标志物，开发并测试了2种定量聚合酶链反应（PCR）测定法以确定KSHV外周血单核细胞（PBMC）病毒载量。通过定量竞争（QC）和实时应用生物系统（ABI）PCR，大多数具有良好预后的KS患者（13/15）的KSMC拷贝数为≤1.5log KSHV / 10（5）PBMC。两种测定均提供94％的特异性，可用于在20个月的随访期间鉴定16例无KS进展的患者。 QC-PCR和ABI-PCR分别显示出100％和80％的诊断敏感性水平，以鉴定5例KS进展的患者。二分型的人类免疫缺陷病毒载量和二分型的CD4计数均不能预测KS进展或KS临床阶段（所有阳性预测值<30％）。这些结果证明，KS患者中循环KSHV的数量具有生物学意义，并且可以以足够的准确度进行测量以提供临床有用的信息。

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来源
《The Journal of Infectious Diseases》 |2002年第12期|共9页
作者
Quinlivan EB; Zhang C; Stewart PW; Komoltri C; Davis MG; Wehbie RS;
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正文语种 eng
中图分类传染病;
关键词
Kaposi Sarcoma; Herpesvirus 8; Human; Polymerase Chain Reaction; High; Progression; 疱疹病毒8; 人; 聚合酶链反应;

机译：Kaposi Sarcoma;Herpesvirus 8;Human;Polymerase Chain Reaction;High;Progression;疱疹病毒8;人;聚合酶链反应;

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1. Elevated Virus Loads of Kaposi's Sarcoma-Associated Human Herpesvirus 8 Predict Kaposi's Sarcoma Disease Progression, but Elevated Levels of Human Immunodeficiency Virus Type 1 Do Not. [J] . Quinlivan EB, Zhang C, Stewart PW, The Journal of Infectious Diseases . 2002,第12期

机译：卡波西氏肉瘤相关人类疱疹病毒的病毒载量升高8预测卡波西氏肉瘤疾病的进展，但人类免疫缺陷病毒1型水平升高却没有。
2. Kaposi sarcoma-associated herpesvirus (human herpesvirus type 8)-associated extracavitary lymphoma: Report of a case in an HIV-positive patient with simultaneous kaposi sarcoma and a review of the literature. [J] . Zhang H, Yang XY, Hong T, Acta Haematologica . 2010,第4期

机译：卡波西氏肉瘤相关的疱疹病毒（人类疱疹病毒8型）相关的腔外淋巴瘤：HIV阳性患者同时卡波西氏肉瘤的一例报道和文献复习。
3. Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and human immunodeficiency virus (HIV) in relation to the risk and clinical presentation of Kaposi's sarcoma in Uganda [J] . R Newton, J Ziegler, D Bourboulia, British Journal of Cancer . 2003,第3期

机译：在乌干达感染卡波西氏肉瘤相关疱疹病毒（KSHV）和人免疫缺陷病毒（HIV），与卡波西氏肉瘤的风险和临床表现有关
4. A system based approach to construct a Kaposi sarcoma-associated herpesvirus (KSHV) specific pathway crosstalk network [C] . Daali Amy Wafa, Huang Yufei, Jamshidi Mo International Conference on System of Systems Engineering . 2013

机译：基于系统的方法来构建卡波济氏肉瘤相关疱疹病毒（KSHV）特异性途径串扰网络
5. Transcriptional regulation of polyadenylated nuclear RNA by RTA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 [D] . Song, Moon Jung 2002

机译：卡波西氏肉瘤相关疱疹病毒/人疱疹病毒中RTA对多腺苷酸化核RNA的转录调控8
6. Human herpesvirus 8 (Kaposis sarcoma-associated herpesvirus) DNA in Kaposis sarcoma lesions AIDS Kaposis sarcoma cell lines endothelial Kaposis sarcoma simulators and the skin of immunosuppressed patients. [O] . M. Dictor, E. Rambech, D. Way, 1996

机译：卡波西氏肉瘤病变中的人类疱疹病毒8（卡波西氏肉瘤相关疱疹病毒）DNA艾滋病卡波西氏肉瘤细胞系内皮卡波西氏肉瘤模拟器和免疫抑制患者的皮肤。
7. Elevated Virus Loads of Kaposi’s Sarcoma–Associated Human Herpesvirus 8 Predict Kaposi's Sarcoma Disease Progression, but Elevated Levels of Human Immunodeficiency Virus Type 1 Do Not [O] . E. Byrd Quinlivan, Chuan Zhang, Paul W. Stewart, 2002

机译：Kaposi的肉瘤病毒负荷升高的病毒负荷预测Kaposi的肉瘤疾病进展，但人类免疫缺陷病毒类型的升高程度1没有
8. Report on Carcinogens (RoC) Concept: Selected Viruses. Epstein--Barr Virus, Human ImmunodeficiencynVirus Type 1, Human T--Cell Lymphotropic Virus Type 1, Kaposi Sarcoma--Associated Herpes Virus, and nMerkel Cell Polyoma Virus. [R] . 2016

机译：关于致癌物（RoC）概念的报告：选定的病毒。爱泼斯坦 - 巴尔病毒，人类免疫缺陷病毒1型，人类T细胞淋巴细胞病毒1型，卡波西肉瘤 - 相关疱疹病毒和nmerkel细胞多瘤病毒。

Elevated Virus Loads of Kaposi's Sarcoma-Associated Human Herpesvirus 8 Predict Kaposi's Sarcoma Disease Progression, but Elevated Levels of Human Immunodeficiency Virus Type 1 Do Not.

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