Selective solid phase extraction of a drug lead compound using molecularly imprinted polymers prepared by the target analogue approach

Dirion B.; Lanza F.; Sellergren B.; Chassaing C.; Venn R.; Berggren C.

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Selective solid phase extraction of a drug lead compound using molecularly imprinted polymers prepared by the target analogue approach

机译：使用目标类似物方法制备的分子印迹聚合物对药物前导化合物进行选择性固相萃取

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Molecularly imprinted polymers have been evaluated at the sample clean-up stage in the analysis of a drug lead compound. In order to circumvent quantification problems related to bleeding of the template, a structurally related analogue of the latter was used. This was selected based on criteria related to interaction site location, solubility, availability and stability of the analogue. Selection of suitable polymerisation conditions was then made using a small batch format (ca. 50 mg) and rapid assessment of binding in the equilibrium mode. It was found that the amount of template could be greatly reduced compared to the conventional protocol, requiring only 5 mumol of template per gram of polymer without seriously compromising the performance of the materials for chromatographic or SPE applications. [References: 13]

机译：在药物前导化合物的分析中，已经在样品净化阶段对分子印迹聚合物进行了评估。为了规避与模板渗色有关的量化问题，使用了模板的结构相关类似物。根据与相互作用部位的位置，类似物的溶解度，可用性和稳定性有关的标准进行选择。然后使用小批量形式（约50 mg）选择合适的聚合条件，并以平衡模式快速评估结合。已经发现，与常规方案相比，模板的量可以大大减少，每克聚合物仅需要5μmol模板，而不会严重损害用于色谱或SPE应用的材料的性能。 [参考：13]

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《Chromatographia》 |2002年第4期|共5页
作者
Dirion B.; Lanza F.; Sellergren B.; Chassaing C.; Venn R.; Berggren C.;
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正文语种 eng
中图分类分析化学;
关键词
Solid phase extraction; Column liquid chromatography; Molecularly imprinted polymers; Drug analysis; Recognition; Sorbents;

机译：固相萃取柱液相色谱分子印迹聚合物药物分析识别吸附剂;

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1. Selective solid phase extraction of a drug lead compound using molecularly imprinted polymers prepared by the target analogue approach [J] . Dirion B., Lanza F., Sellergren B., Chromatographia . 2002,第3a4期

机译：使用目标类似物方法制备的分子印迹聚合物对药物前导化合物进行选择性固相萃取
2. Preparation and evaluation of solid-phase microextraction fibers based on monolithic molecularly imprinted polymers for selective extraction of diacetylmorphine and analogous compounds [J] . Djozan D, Baheri T Journal of chromatography, A: Including electrophoresis and other separation methods . 2007,第1a2期

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3. Preparation of Molecularly Imprinted Polymer Monolith with an Analogue of Thiamphenicol and Application to Selective Solid-Phase Microextraction [J] . Chao Ma, Hui Chen, Na Sun, Food Analytical Methods . 2012,第6期

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4. Class-Selective Extraction of Streptomycin and Related Drugs from Pork Tissue Using Molecularly Imprinted Polymer SPE and LC-MS/MS [C] . Emily R. Barrey, Michael Ye, Olga I. Shimelis ASMS Conference on Mass Spectrometry and Allied Topics . 2014

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5. Development of Magnetic Molecularly Imprinted Polymer Nanoparticles for Rapid and Selective Removal of Endocrine Disrupting Compounds from Aqueous Environment. [D] . Xia, Xinlong. 2012

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6. Combining Pickering Emulsion Polymerization with Molecular Imprinting to Prepare Polymer Microspheres for Selective Solid-Phase Extraction of Malachite Green [O] . Weixin Liang, Huawen Hu, Pengran Guo, 2017

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7. Solid-phase extraction using molecularly imprinted polymer for selective extraction of natural and syntetic estrogens from aqueous samples [O] . Lucci Paolo, Núñez Burcio Oscar, Galcerán Huguet M. Teresa 2016

机译：使用分子印迹聚合物固相萃取从水性样品中选择性萃取天然和合成雌激素

Selective solid phase extraction of a drug lead compound using molecularly imprinted polymers prepared by the target analogue approach

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