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首页> 外文期刊>The Journal of Infectious Diseases >Antibody Responses to Plasmodium falciparum Merozoite Surface Protein-1 and Efficacy of Amodiaquine in Gabonese Children with P. falciparum Malaria.
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Antibody Responses to Plasmodium falciparum Merozoite Surface Protein-1 and Efficacy of Amodiaquine in Gabonese Children with P. falciparum Malaria.

机译：对恶性疟原虫疟疾的加蓬儿童中对恶性疟原虫裂殖子表面蛋白-1的抗体反应和阿莫地喹的功效。

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摘要

The relationship between the efficacy of amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria and preexisting antibodies against merozoite surface protein (MSP)-1, a blood-stage P. falciparum antigen, was investigated. The immunoglobulin G antibody response to different MSP-1 recombinant proteins was evaluated in plasma samples from Gabonese children with uncomplicated malaria who were treated with amodiaquine. The prevalence of anti-MSP-1 antibodies was similar among patients with either parasitological and clinical cure after treatment (n=102) or treatment failure (n=51) by day 28 (83% in both groups). However, associations between antibody responses to K1 and MAD20 allelic families and therapeutic success were found (P<.001 and P=.034, respectively). A high proportion of plasma samples recognizing several antigens was found in the cured group. This association was significant even when data were stratified by age, particularly for the K1 family antigens (P=.029). These results suggest that humoral immune responses play a supportive role in the efficacy of amodiaquine treatment.
机译：研究了阿莫地喹治疗单纯性恶性疟原虫疟疾的功效与抗疟原虫表面蛋白（MSP）-1（一种血液阶段的恶性疟原虫抗原）的现有抗体之间的关系。在加莫地喹治疗的加蓬患有单纯性疟疾的儿童血浆样品中评估了对不同MSP-1重组蛋白的免疫球蛋白G抗体反应。在治疗后第28天，寄生虫病和临床治愈（n = 102）或治疗失败（n = 51）的患者中，抗MSP-1抗体的患病率相似（两组均为83％）。但是，发现对K1和MAD20等位基因家族的抗体反应与治疗成功之间存在关联（分别为P <.001和P = .034）。在治愈组中发现大量识别多种抗原的血浆样品。即使按年龄对数据进行分层（尤其是针对K1家族抗原），这种关联也很明显（P = .029）。这些结果表明，体液免疫应答在阿莫地喹治疗的疗效中起支持作用。

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