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首页> 外文期刊>The Journal of Infectious Diseases >GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype.
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GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype.

机译：接受HCV治疗的丙型肝炎病毒（HCV）/ HIV感染患者中的GB病毒C（GBV-C）感染：GBV-C基因型的重要性。

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BACKGROUND: Persistent GB virus C (GBV-C) coinfection leads to slower human immunodeficiency virus (HIV) progression. Despite the existence of multiple GBV-C genotypes, their relevance to the progression of HIV disease is unknown. We therefore investigated (1) the prevalence and genotype of GBV-C in hepatitis C virus (HCV)/HIV-coinfected patients and (2) the impact of HCV treatment on GBV-C RNA clearance. METHODS: We retrospectively studied 130 HCV/HIV-coinfected patients initiating HCV therapy. Anti-E2 enzyme-linked immunosorbent assay, reverse-transcription polymerase chain reaction (PCR), and real-time PCR were used to detect and quantify GBV-C infection. GBV-C genotype was determined by sequencing the 5' untranslated region. RESULTS: GBV-C infection (past or current) was identified in 111 (85%) of the patients. Ongoing GBV-C replication was detected in 40 patients. Coinfection with GBV-C genotype 2 was associated with significantly higher CD4(+) cell counts. After 24 weeks of HCV therapy, GBV-C RNAclearance was observed in 50% of patients, although this was not associated with changes in HIV load or with CD4(+) cell counts. Sustained GBV-C RNA clearance was observed in 31% of patients with GBV-C RNA detected at baseline. CONCLUSIONS: GBV-C coinfection was extremely common. GBV-C RNA clearance with HCV therapy was associated with neither short-term loss of HIV control nor impaired immune status. The association of GBV-C genotype 2 with higher CD4(+) cell counts merits further study.
机译：背景：持久性GB病毒C（GBV-C）合并感染导致人类免疫缺陷病毒（HIV）进程减慢。尽管存在多种GBV-C基因型，但它们与HIV疾病进展的相关性尚不清楚。因此，我们调查了（1）丙型肝炎病毒（HCV）/ HIV感染患者中GBV-C的患病率和基因型，以及（2）HCV治疗对GBV-C RNA清除率的影响。方法：我们回顾性研究了130名开始HCV治疗的HCV / HIV感染患者。抗E2酶联免疫吸附测定，逆转录聚合酶链反应（PCR）和实时PCR用于检测和定量GBV-C感染。 GBV-C基因型是通过对5'非翻译区进行测序来确定的。结果：在111名患者（85％）中发现了GBV-C感染（过去或现在）。在40例患者中检测到正在进行的GBV-C复制。与GBV-C基因型2的共感染与CD4（+）细胞计数明显升高有关。 HCV治疗24周后，在50％的患者中观察到GBV-C RNA清除，尽管这与HIV负荷变化或CD4（+）细胞计数无关。在基线时检测到的31％的GBV-C RNA患者中观察到持续的GBV-C RNA清除率。结论：GBV-C合并感染极为常见。 HCV治疗清除GBV-C RNA与短期失去HIV控制或免疫状况均不相关。 GBV-C基因型2与较高CD4（+）细胞计数的关联值得进一步研究。

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