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首页> 外文期刊>The Journal of Infectious Diseases >Experimental Pneumocystis carinii Pneumonia in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
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Experimental Pneumocystis carinii Pneumonia in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

机译：猿猴免疫缺陷病毒感染的恒河猴的实验性卡氏肺孢子虫肺炎。

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摘要

To establish experimental Pneumocystis carinii infection in simian immunodeficiency virus (SIV)-infected macaques as a model of acquired immunodeficiency syndrome (AIDS)-associated P. carinii pneumonia (PCP), SIV-infected macaques were inoculated intrabronchially with macaque-derived P. carinii, and P. carinii-specific polymerase chain reaction (PCR) and flow cytometric analysis of bronchoalveolar lavage fluid were done biweekly for up to 44 weeks after inoculation. All inoculated animals had a P. carinii-specific PCR product after infection. CD8(+) T cells in lung lavage samples from SIV- and P. carinii-coinfected animals increased to >90% of total CD3(+) cells, a pattern associated with naturally acquired P. carinii infection. Progression of disease also was correlated with increased neutrophil infiltration to the lungs. The animals had a protracted period of asymptomatic colonization with P. carinii before progression to PCP. The development of a model of PCP in SIV-infected rhesus macaques providesthe means to study AIDS-associated PCP.
机译：为了在猿猴免疫缺陷病毒（SIV）感染的猕猴中建立实验性卡氏肺孢子虫感染作为获得性免疫缺陷综合症（AIDS）相关的卡氏肺炎（PCP）的模型，将SIV感染的猕猴与猕猴衍生的卡氏疟原虫在支气管内接种。接种后每两周进行一次卡氏疟原虫特异性聚合酶链反应（PCR）和支气管肺泡灌洗液流式细胞仪分析，历时长达44周。感染后所有接种的动物均具有卡氏疟原虫特异性PCR产物。来自SIV-和卡氏疟原虫共感染动物的肺灌洗样本中的CD8（+）T细胞增加到总CD3（+）细胞的> 90％，这种模式与自然获得的卡氏疟原虫感染相关。疾病的进展也与中性粒细胞向肺部浸润的增加有关。在发展为PCP之前，动物在Cari​​nii上无症状定居的时间很长。 SIV感染恒河猴的PCP模型的开发提供了研究与艾滋病相关的PCP的手段。

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