Human Herpesvirus 6 Latency Characterized by High Viral Load: Chromosomal Integration in Many, but Not All, Cells

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Human Herpesvirus 6 Latency Characterized by High Viral Load: Chromosomal Integration in Many, but Not All, Cells

机译：高病毒载量表征的人类疱疹病毒6潜伏期：许多但不是全部细胞中的染色体整合

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We read with great interest the study by Clark et al. that reported the transmission of human, herpesvirus (HHV)-6 genome, integrated on chromosome band 17pl3.3, through stem cell transplantation . This finding indicates that a high HHV-6 load in the peripheral blood/serum is not necessarily indicative of an active infection, which would require clinical intervention, but, rather, may be indicative of a type of latent infection characterized by the integration state of HHV-6.

机译：我们非常感兴趣地阅读了Clark等人的研究。报道了通过干细胞移植整合在染色体带17pl3.3上的人类疱疹病毒（HHV）-6基因组的传播。这一发现表明，外周血/血清中的高HHV-6负荷量不一定表示活动性感染，这需要临床干预，而可能表示一种潜在的感染类型，其特征在于感染的整合状态HHV-6。

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《The Journal of Infectious Diseases》 |2006年第7期|共2页
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1. Human Herpesvirus 6 Latency Characterized by High Viral Load: Chromosomal Integration in Many, but Not All, Cells [J] . The Journal of Infectious Diseases . 2006,第7期

机译：高病毒载量表征的人类疱疹病毒6潜伏期：许多但不是全部细胞中的染色体整合
2. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro [J] . Jesse H. Arbuckle, Maria M. Medveczky, Janos Luka, Proceedings of the National Academy of Sciences of the United States of America . 2010,第12期

机译：潜在的人类疱疹病毒6A基因组在体内和体外特异性整合到人类染色体的端粒中
3. Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. [J] . Gao SJ, Zhang YJ, Deng JH, The Journal of Infectious Diseases . 1999,第5期

机译：卡波西氏肉瘤相关疱疹病毒（人类疱疹病毒8）潜伏性核抗原的分子多态性：证明了病毒基因型的大量组成和不同病毒基因型的双重感染。
4. Comparison of the Diagnostic Sensitivity of Nasopharyngeal and Nasal Swabs and Use of Viral Loads for the Molecular Diagnosis of Equine Herpesvirus-1 Infection [C] . Nicola Pusterla, Samantha Mapes, W. David Wilson Annual Convention of the American Association of Equine Practitioners . 2007

机译：鼻咽癌和鼻拭子诊断敏感性的比较，以及病毒载荷的分子诊断血疱疮1感染
5. Identification and Characterization of the Human Herpesviruses 6A and 6B Genome Integration into Telomeres of Human Chromosomes during Latency. [D] . Arbuckle, Jesse Herbert. 2011

机译：人疱疹病毒6A和6B基因组在潜伏期整合入人类染色体端粒的鉴定和表征。
6. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro [O] . Jesse H. Arbuckle, Maria M. Medveczky, Janos Luka, 2010

机译：潜在的人类疱疹病毒6A基因组在体内和体外特异性整合到人类染色体的端粒中
7. Human Herpesvirus 6 Latency Characterized by High Viral Load: Chromosomal Integration in Many, but Not All, Cells [O] . Mario Luppi, Patrizia Barozzi, Raffaella Bosco, 2006

机译：人类疱疹病毒6潜伏期，其特征在于高病毒载荷：许多染色体集成，但不是全部，细胞

Human Herpesvirus 6 Latency Characterized by High Viral Load: Chromosomal Integration in Many, but Not All, Cells

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