Building models for keratin disorders

KosterM.I.

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Building models for keratin disorders

机译：角蛋白疾病的构建模型

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Palmoplantar keratoderma is a hallmark of pachyonychia congenita (PC) and focal non-epidermolytic palmoplantar keratoderma (FNEPPK). By generating keratin 16 (Krt16)-deficient mice, Lessard and Coulombe, as described in this issue, have generated a mouse model to replicate these palmoplantar lesions. Studies using this model may provide novel insights into the molecular mechanisms responsible for the formation of palmoplantar lesions in PC and FNEPPK patients.

机译：掌plant角化病是先天性肺炎（PCchyonychia）和局灶性非表皮溶解性掌plant角化病（FNEPPK）的标志。如本期所述，通过生成角蛋白16（Krt16）缺陷型小鼠，Lessard和Coulombe已生成了复制这些掌足病变的小鼠模型。使用该模型的研究可能会为PC和FNEPPK患者中掌plant病变形成的分子机制提供新颖的见解。

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《The Journal of investigative dermatology.》 |2012年第5期|共3页
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正文语种 eng
中图分类皮肤病学与性病学;
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Building models for keratin disorders

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