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首页> 外文期刊>The Journal of investigative dermatology. >Evidence of differentiation in myeloid malignancies associated neutrophilic dermatosis: A fluorescent in situ hybridization study of 14 patients
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Evidence of differentiation in myeloid malignancies associated neutrophilic dermatosis: A fluorescent in situ hybridization study of 14 patients

机译：骨髓恶性肿瘤相关嗜中性粒细胞性皮肤病分化的证据：14位患者的荧光原位杂交研究

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TO THE EDITOR Neutrophilic dermatoses (NDs) are characterized by dense infiltrates of mature neutrophils typically located in the upper dermis. Despite having dissimilar clinical presentations, Sweet's syndrome, pyoderma gangrenosum, neutrophilic eccrine hidradenitis, and other related disorders are recognized as part of the spectrum of NDs because of their overlapping clinical and histopatho-logical findings (Vignon-Pennamen and Wallach, 1991). Although most instances of ND have a benign course, some extracutaneous localizations of the neutrophilic infiltrates can be potentially life-threatening (Vignon-Pennamen, 2000). Little is known about the patho-physiology of ND. The findings of high CD3, IL-1, IL-8, and tumor necrosis factor-alpha expressions by immunohisto-chemical staining in the dermis of ND patients (Marzano et ai, 2010) and the impressive effects of corticosteroids in alleviating these diseases have underlined a role for activated T lymphocytes in the recruitment of mature neutrophils to the dermis.
机译：致编者中性粒细胞性皮肤病（NDs）的特征是通常位于真皮上部的成熟中性粒细胞密集浸润。尽管临床表现有所不同，但由于其临床和组织病理学发现重叠，Sweet's综合征，坏疽性脓皮病，中性粒细胞分泌腺炎和其他相关疾病被认为是ND的一部分（Vignon-Pennamen和Wallach，1991）。尽管大多数ND患者的病程都是良性的，但中性粒细胞浸润的一些皮下定位可能会威胁生命（Vignon-Pennamen，2000）。关于ND的病理生理学知之甚少。通过免疫组化染色在ND患者的真皮中发现高CD3，IL-1，IL-8和肿瘤坏死因子-α的表达（Marzano等，2010），以及皮质类固醇在缓解这些疾病方面的令人印象深刻的作用强调了活化的T淋巴细胞在将成熟的中性粒细胞募集到真皮中的作用。

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