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首页> 外文期刊>The Journal of investigative dermatology. >Differential Changes in the Peptidergic and the Non-Peptidergic Skin Innervation in Rat Models for Inflammation, Dry Skin Itch, and Dermatitis
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Differential Changes in the Peptidergic and the Non-Peptidergic Skin Innervation in Rat Models for Inflammation, Dry Skin Itch, and Dermatitis

机译：在炎症，干性皮肤瘙痒和皮炎的大鼠模型中，肽能和非肽能神经支配的差异性变化

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摘要

Skin innervation is a dynamic process that may lead to changes in nerve fiber density during pathological conditions. We have investigated changes in epidermal nerve fiber density in three different rat models that selectively produce chronic itch (the dry skin model), or itch and inflammation (the dermatitis model), or chronic inflammation without itch (the CFA model). In the epidermis, we identified peptidergic fibers that is, immunoreactive (IR) for calcitonin gene-related peptide or substance P-and non-peptidergic fibers that is, IR for P2X3. The overall density of nerve fibers was determined using IR for the protein gene product 9.5. In all three models, the density of epidermal peptidergic nerve fibers increased up to five times when compared with a sham-treated control group. In contrast, the density of epidermal non-peptidergic fibers was not increased, except for a small but significant increase in the dry skin model. Chronic inflammation showed an increased density of peptidergic fibers without itch, indicating that increased nerve fiber density is not invariably associated. with itch. The finding that different types of skin pathology induced differential changes in nerve fiber density may be used as a diagnostic tool in humans, through skin biopsies, to identify different types of pathology and to monitor the effect of therapies.
机译：皮肤神经支配是一个动态过程，可能导致病理状态下神经纤维密度发生变化。我们研究了三种不同大鼠模型中表皮神经纤维密度的变化，这些模型选择性地产生慢性瘙痒（皮肤干燥模型），瘙痒和炎症（皮炎模型）或无瘙痒的慢性炎症（CFA模型）。在表皮中，我们确定了降钙素基因相关肽或物质P的免疫反应性（IR）肽能纤维，以及P2X3的非肽能纤维。用IR测定蛋白质基因产物9.5的神经纤维总密度。在所有三个模型中，与假治疗的对照组相比，表皮肽能神经纤维的密度增加了五倍。相反，表皮非肽能纤维的密度没有增加，除了干性皮肤模型有少量但显着的增加。慢性炎症显示肽能纤维的密度增加而没有瘙痒，表明神经纤维密度的增加并非总是相关的。发痒。通过皮肤活检，不同类型的皮肤病理学引起神经纤维密度差异变化的发现可以用作人类的诊断工具，以识别不同类型的病理学并监测治疗效果。

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