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首页> 外文期刊>The Journal of investigative dermatology. >The Immune Response to Skin Trauma Is Dependent on the Etiology of Injury in a Mouse Model of Burn and Excision
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The Immune Response to Skin Trauma Is Dependent on the Etiology of Injury in a Mouse Model of Burn and Excision

机译：对皮肤外伤的免疫反应取决于烧伤和切除小鼠模型中损伤的病因

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摘要

Skin trauma has many different causes including incision, blunt force, and burn. All of these traumas trigger an immune response. However, it is currently unclear whether the immune response is specific to the etiology of the injury. This study was established to determine whether the immune response to excision and burn injury of equivalent extent was the same. Using a mouse model of a full-thickness 19 mm diameter excision or 19 mm diameter full-thickness burn injury, we examined the innate immune response at the level of serum cytokine induction, whole-blood lymphocyte populations, dendritic cell function/phenotype, and the ensuing adaptive immune responses of CD4 and CD8 T-cell populations. Strikingly, both the innate and adaptive immune system responses differed between the burn and excision injuries. Acute cytokine induction was faster and different in profile to that of excision injury, leading to changes in systemic monocyte and neutrophil levels. Differences in the immune profile between burn and excision were also noted up to day 84 post injury, suggesting that the etiology of injury leads to sustained changes in the response. This may in part underlie clinical observations of differences in patient morbidity and mortality in response to different skin injury types.
机译：皮肤创伤有许多不同的原因，包括切口，钝力和烧伤。所有这些创伤都会触发免疫反应。但是，目前尚不清楚免疫应答是否对损伤的病因具有特异性。建立该研究以确定对切除和烧伤的免疫反应是否相同。使用直径为19 mm的全层切除或直径为19 mm的全层烧伤的小鼠模型，我们在血清细胞因子诱导水平，全血淋巴细胞数量，树突状细胞功能/表型和水平上检查了先天免疫应答随后的CD4和CD8 T细胞群体的适应性免疫反应。引人注目的是，烧伤和切除损伤之间的先天性和适应性免疫系统反应都不同。急性细胞因子的诱导更快，且与切除损伤的诱导谱不同，从而导致全身单核细胞和中性粒细胞水平发生变化。直至受伤后第84天，烧伤和切除之间的免疫特征也有所不同，这表明受伤的病因导致反应的持续变化。这可能部分是由于临床观察不同皮肤损伤类型引起的患者发病率和死亡率差异的基础。

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