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首页> 外文期刊>The Journal of investigative dermatology. >Sequential Observation of Morphogenesis of Cutaneous Nerve Fibers in Fetal Rat Skin: An Immunohistochemical and Electron Microscopic Study.
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Sequential Observation of Morphogenesis of Cutaneous Nerve Fibers in Fetal Rat Skin: An Immunohistochemical and Electron Microscopic Study.

机译：胎鼠皮肤皮肤神经纤维形态发生的顺序观察：一项免疫组织化学和电子显微镜研究。

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摘要

Skin of DA/Slc rat fetuses removed on the fetal days 11 to 20 and on delivery day (21 days post-fertilization) was used. In the immunohistochemistry, the anti-neurofilament 69 kDa (NF68)-positive fibers appeared in the subepidermal dermis on the fetal day 12. The subepidermal and intraepidermal NF68-positive fibers reached to a maximum number on the fetal day 14. They disappeared completely on the fetal day 16. After the fetal day 19, a small number of the subepidermal and intraepidermal NF68-positive fibers were seen again. As for anti-nerve growth factor (NGF), intermediate cells, spinous cells and granular cells of the epidermis showed strongly positive stain. In the electron microscopy, there were bundles of immature axons which were packed by abundant microtubules and neurofilaments during the entire fetal period. On the fetal days 16 and 17, a considerable number of axons showed severe degenerative changes. From these findings, the subepidermal and intraepidermal nerve fibers in the fetal rat skin increased temporarily to a maximum number, and soon after they disappeared completely, followed by another period of re-appearance until delivery day. Such a dynamic change of the number of the cutaneous nerve fibers was not synchronous with expression of NGF of the epidermal cells.
机译：使用在胎儿第11至20天和分娩日（受精后21天）去除DA / Slc大鼠胎儿的皮肤。在免疫组织化学中，在胎儿第12天出现在表皮下真皮中的抗神经长丝69 kDa（NF68）阳性纤维。在胎儿第14天时，表皮下和表皮内NF68阳性纤维达到最大数量。在胎儿第19天之后，在胎儿第19天之后，再次看到少量表皮下和表皮内NF68阳性纤维。对于抗神经生长因子（NGF），表皮的中间细胞，棘细胞和颗粒细胞显示强阳性染色。在电子显微镜下，在整个胎儿期间，有大量未成熟的轴突束被大量的微管和神经丝包裹。在胎儿的第16天和第17天，大量的轴突显示出严重的退行性变化。根据这些发现，胎鼠皮肤中的表皮下和表皮内神经纤维暂时增加至最大数量，并在它们完全消失后不久，随后又出现了一段新的时期直到分娩日。皮肤神经纤维数量的这种动态变化与表皮细胞的NGF表达不同步。

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