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首页> 外文期刊>The Journal of investigative dermatology. >Regulation of Wheal and Flare by Tea Tree Oil: Complementary Human and Rodent Studies.
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Regulation of Wheal and Flare by Tea Tree Oil: Complementary Human and Rodent Studies.

机译：茶树油对鲸鱼和火炬的调节：人体和啮齿动物的补充研究。

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When applied 20 min after injection of histamine into human forearm skin, tea tree oil (TTO) reduces the developing cutaneous vascular response. In this study, the effect of TTO on inflammatory microvascular changes was dissected at the base of an experimental blister on rat skin. 1,8-Cineole, representing 2% of TTO, reduced vascular changes induced by sensory neuropeptides released when the distal portion of a cut sciatic nerve was electrically stimulated. The pre-terminal modulatory effect of 1,8-Cineole was confirmed in tests in sensory-denervated rats. Terpinen-4-ol (approximately 40% TTO) reduced substance P-induced microvascular changes and protein extravasation by a direct nitric oxide-mediated effect on the microvasculature, without sensory nerve involvement. alpha-Terpineol (3% of TTO) regulated both pre- and post-sensory nerve terminals. In human skin, terpinen-4-ol applied 10 min after histamine injection, but not alpha-terpineol or 1,8-cineole, regulated the developing wheal and flare suggesting that the histamine-induced responses in humans (at the dose used in this study, 50 microL of 330 microM histamine) are in large part determined by histamine directly affecting the vasculature via post-terminal-mediated events. The underlying strength of these studies is the use of a well-established rat physiologic model to differentiate the mechanism of regulation of microvascular changes by modulatory agents.
机译：在将组胺注射到人前臂皮肤中20分钟后，茶树油（TTO）可以减少正在形成的皮肤血管反应。在这项研究中，在大鼠皮肤上的实验性水泡的底部剖析了TTO对炎症性微血管变化的影响。 1,8-Cineole（占TTO的2％）减少了因电刺激坐骨神经切开的远端部分时释放的感觉神经肽诱导的血管变化。在感觉去神经的大鼠的试验中证实了1，8-Cineole的末端调节作用。 Terpinen-4-ol（约40％TTO）通过一氧化氮介导的对微脉管系统的直接作用而减少了物质P诱导的微血管变化和蛋白质外渗，而没有感觉神经的参与。 α-松油醇（占TTO的3％）调节感觉神经末梢。在人皮肤中，在注射组胺后10分钟施用terpinen-4-ol，而不是α-萜品醇或1,8-cineole调节发育中的鲸鱼和耀斑，这表明组胺在人体内引起的反应（以这种剂量使用）在一项研究中，330 microM组胺中的50 microL很大程度上是由组胺通过末端介导的事件直接影响脉管系统确定的。这些研究的潜在优势是使用成熟的大鼠生理模型来区分调节剂对微血管变化的调节机制。

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