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首页> 外文期刊>The Journal of investigative dermatology. >Cerebral processing of histamine-induced itch using short-term alternating temperature modulation--an FMRI study.
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Cerebral processing of histamine-induced itch using short-term alternating temperature modulation--an FMRI study.

机译：使用短期交替温度调制的脑处理组胺诱发的瘙痒-FMRI研究。

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摘要

Human neuroimaging studies on the physiology of itch have been hampered by the lack of reproducible "on-off" stimuli. Using a previously established biphasic temperature stimulus model, we investigated the cerebral activation pattern of itch processing in 12 healthy volunteers with functional magnetic resonance imaging. Itch was provoked on the right forearm with skin prick application of 1% histamine-dihydrochloride. Local temperature modulation allowed reproducible itch provocation above scratch threshold (defined as 33/100 on a visual analogue scale) during 25 degrees C, whereas itch declined below scratch threshold during the 32 degrees C stimulation period. No itch sensation was reported using 0.9% saline with temperature modulation. Itch sensation above scratch threshold was associated with increased activation of the thalamus, presupplementary motor area, anterior insular, inferior parietal, and dorsolateral prefrontal cortex, and decreased activation of the orbitofrontal, medial frontal, mid-cingulate, and primary motor cortex in comparison to saline. The biphasic temperature model allows rapid modulation of histamine-induced itch. The evoked itch sensation above scratch threshold is processed by a network of brain regions contributing to the encoding of sensory, emotional, attention-dependent, cognitive-evaluative and motivational aspects of itch.
机译：由于缺乏可重复的“开-关”刺激，人类对瘙痒生理的神经影像学研究受到了阻碍。使用先前建立的双相温度刺激模型，我们使用功能磁共振成像技术调查了12名健康志愿者的瘙痒处理的大脑激活模式。皮肤点刺施用1％组胺-二盐酸盐刺激右前臂发痒。局部温度调节允许在25摄氏度期间高于划伤阈值（在视觉模拟标度上定义为33/100）的可再生瘙痒刺激，而在32摄氏度刺激期间，瘙痒下降至划伤阈值以下。使用0.9％的生理盐水调节温度时，未见痒感。高于划痕阈值的瘙痒感觉与丘脑，辅助运动区，前岛突，顶叶壁和背外侧前额叶皮层的激活增加有关，与眶额，内侧额叶，中扣带和原发性运动皮层的激活减少有关盐水。双相温度模型允许快速调节组胺诱导的瘙痒。高于刮擦阈值的诱发的瘙痒感觉是由大脑区域网络处理的，该网络有助于对瘙痒的感觉，情绪，注意力，认知评估和动机方面进行编码。

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