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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >A cholinergic synaptically triggered event participates in the generation of persistent activity necessary for eye fixation.
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A cholinergic synaptically triggered event participates in the generation of persistent activity necessary for eye fixation.

机译：胆碱能的突触触发事件参与了眼睛固定所必需的持续活动的产生。

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摘要

An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing. A persisting firing seems to be necessary for postural maintenance after a previous movement. We have studied in vitro and in vivo the generation of the persistent neuronal activity responsible for eye fixation after spontaneous eye movements. Rat sagittal brainstem slices were used for the intracellular recording of prepositus hypoglossi (PH) neurons and their synaptic activation from nearby paramedian pontine reticular formation (PPRF) neurons. Single electrical pulses applied to the PPRF showed a monosynaptic glutamatergic projection on PH neurons, acting on AMPA-kainate receptors. Train stimulation of the PPRF area evoked a sustained depolarization of PH neurons exceeding (by hundreds of milliseconds) stimulus duration. Both duration and amplitude of this sustained depolarization were linearly related to train frequency. The train-evoked sustained depolarization was the result of interaction between glutamatergic excitatory burst neurons and cholinergic mesopontine reticular fibers projecting onto PH neurons, because it was prevented by slice superfusion with cholinergic antagonists and mimicked by cholinergic agonists. As expected, microinjections of cholinergic antagonists in the PH nucleus of alert behaving cats evoked a gaze-holding deficit consisting of a re-centering drift of the eye after each saccade. These findings suggest that a slow, cholinergic, synaptically triggered event participates in the generation of persistent activity characteristic of PH neurons carrying eye position signals.
机译：关于神经系统综合特性的一个令人兴奋的话题是短暂的运动命令或短暂的感觉刺激如何能够引起持续的神经元变化，主要是作为持续的，进补的动作电位激发。上次运动后，为了保持姿势，有必要持续射击。我们已经在体外和体内研究了自发性眼球运动后负责眼部固定的持久性神经元活性的产生。大鼠矢状脑干切片用于细胞内记录垂体前叶（PH）神经元及其突触激活附近的桥旁中脑桥状网状结构（PPRF）神经元。施加到PPRF的单个电脉冲在PH神经元上表现出单突触的谷氨酸能投射，作用于AMPA-红藻氨酸受体。 PPRF区域的火车刺激引起PH神经元持续去极化，超过刺激持续时间（数百毫秒）。这种持续去极化的持续时间和幅度都与列车频率成线性关系。火车诱发的持续去极化是谷氨酸能兴奋性爆发神经元与投射到PH神经元上的胆碱能中脑膜网状纤维之间相互作用的结果，因为它可以通过与胆碱能拮抗剂的切片混入来预防，并被胆碱能激动剂模拟。如预期的那样，机敏行为猫的PH核中微量注射胆碱能拮抗剂会引起凝视缺陷，包括每次扫视后眼睛重新居中。这些发现表明，缓慢，胆碱能，突触触发的事件参与了携带眼睛位置信号的PH神经元的持续活动特征的产生。

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