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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Coupled networks of parvalbumin-immunoreactive interneurons in the rat basolateral amygdala.
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Coupled networks of parvalbumin-immunoreactive interneurons in the rat basolateral amygdala.

机译：大鼠基底外侧杏仁核中小白蛋白-免疫反应性中间神经元的耦合网络。

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摘要

Recent studies indicate that the basolateral amygdala exhibits fast rhythmic oscillations during emotional arousal, but the neuronal mechanisms underlying this activity are not known. Similar oscillations in the cerebral cortex are generated by a network of parvalbumin (PV)-immunoreactive interneurons interconnected by chemical synapses and dendritic gap junctions. The present immunoelectron microscopic study revealed that the basolateral amygdalar nucleus (BLa) contains a network of parvalbumin-immunoreactive (PV+) interneurons interconnected by chemical synapses, dendritic gap junctions, and axonal gap junctions. Twenty percent of synapses onto PV+ neurons were formed by PV+ axon terminals. All of these PV+ synapses were symmetrical. PV+ perikarya exhibited the greatest incidence of PV+ synapses (30%), with lower percentages associated with PV+ dendrites (15%) and spines (25%). These synapses comprised half of all symmetrical synapses formed with PV+ cells. A total of 18 dendrodendritic gap junctionsbetween PV+ neurons were observed, mostly involving secondary and more distal dendrites (0.5-1.0 microm thick). Dendritic gap junctions were often in close proximity to PV+ chemical synapses. Six gap junctions were observed between PV+ axon terminals. In most cases, one or both of these terminals formed synapses with the perikarya of principal neurons. This is the first study to describe dendritic gap junctions interconnecting PV+ interneurons in the basolateral amygdala. It also provides the first documentation of gap junctions between interneuronal axon terminals in the mammalian forebrain. These data provide the anatomical basis for a PV+ network that may play a role in the generation of rhythmic oscillations in the BLa during emotional arousal.
机译：最近的研究表明，基底外侧杏仁核在情绪唤起过程中表现出快速的节律性振荡，但是这种活动所基于的神经元机制尚不清楚。大脑皮层中的类似振荡是由通过化学突触和树突间隙连接相互连接的小白蛋白（PV）-免疫反应性中间神经元网络生成的。目前的免疫电子显微镜研究表明，基底外侧杏仁核（BLa）包含由化学突触，树突间隙连接和轴突间隙连接相互连接的小白蛋白-免疫反应性（PV +）中神经元网络。 PV +轴突末端形成了PV +神经元上20％的突触。所有这些PV +突触都是对称的。 PV +周核生物显示出PV +突触的发生率最高（30％），而与PV +树突（15％）和棘突（25％）相关的百分比较低。这些突触占PV +细胞形成的所有对称突触的一半。在PV +神经元之间总共观察到18个树突状树突间隙连接，主要涉及次生和更多的远端树突（0.5-1.0微米厚）。树突间隙连接经常靠近PV +化学突触。在PV +轴突末端之间观察到六个间隙连接。在大多数情况下，这些末端之一或两者都与主要神经元的核周突触形成突触。这是第一项描述基底外侧杏仁核中连接PV +中间神经的树突间隙连接的研究。它还提供了哺乳动物前脑神经元轴突末端之间的间隙连接的第一个文献。这些数据为PV +网络提供了解剖学基础，该网络可能在情绪唤起过程中在BLa的节律性振荡的产生中发挥作用。

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