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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity.
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Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity.

机译：成年小鼠大脑中的骨髓来源的细胞保留了其造血特性。

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摘要

Cytogenesis in the adult brain can result from the recruitment of circulating precursors, but the proposal that some such cells transdifferentiate into neural elements is controversial. We have reinvestigated this issue by following the phenotypic fate of bone marrow cells expressing the green fluorescent protein transplanted into the systemic circulation of irradiated mice. Thousands of donor-derived cells were detected throughout brains of recipients killed 1-12 months after transplantation, but none displayed neuronal, macroglial, or endothelial characteristics, even after injury. Among those that crossed the endothelium of the cerebral cortex, >99.7% were identified as perivascular macrophages. Newly formed parenchymal microglia were found in significant numbers only in the cerebellum and at injury sites. Therefore, bone marrow does supply the mature brain with new specialized cells; however, mesenchymal precursors neither adopt neural phenotypes nor contribute to cerebral vascular remodeling. Thiscontinuous traffic of macrophages across the blood-brain barrier provides a vehicle to introduce therapeutic genes into the nervous system.
机译：成年大脑中的细胞发生可归因于循环前体的募集，但有关某些此类细胞转分化为神经元的提议存在争议。我们通过研究表达绿色荧光蛋白的骨髓细胞的表型命运，对这个问题进行了重新研究，该蛋白被移植到受辐射小鼠的体循环中。在移植后1-12个月内被杀死的受体大脑中检测到成千上万个供体来源的细胞，但即使在受伤后也没有神经元，大胶质细胞或内皮细胞的特征。在穿过大脑皮层内皮细胞​​的那些中，> 99.7％被鉴定为血管周巨噬细胞。仅在小脑和受伤部位发现大量新形成的实质小胶质细胞。因此，骨髓的确为成熟的大脑提供了新的专门细胞。然而，间充质前体既不采用神经表型，也不参与脑血管重构。巨噬细胞连续穿过血脑屏障的运输提供了将治疗性基因引入神经系统的载体。

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