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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Nitric oxide-mediated cortical activation: a diffuse wake-up system.
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Nitric oxide-mediated cortical activation: a diffuse wake-up system.

机译：一氧化氮介导的皮层激活：弥漫的唤醒系统。

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Nitric oxide (NO) has been implicated in some of the central pathways engaged in the regulation of the sleep-wake cycle. The existence of nitric oxide synthase (NOS) in the cholinergic basal forebrain (BF) cells projecting to the cortex suggests a role for NO in the activation induced by the BF during arousal. We tested, in the anesthetized cat, the hypothesis that inhibition of NOS would decrease the ability of BF cholinergic fibers to induce cortical activation. In control conditions, BF stimulation evoked an awake-like EEG pattern (i.e., a decrease in the low-frequency-high-amplitude oscillatory activity and an increase in the high-frequency-low-amplitude activity). After blocking NOS activity, the capacity of BF stimulation to induce cortical activation was strongly impaired. Furthermore, voltammetric measurements of NO levels revealed an increase in cortical NO after BF stimulation, also blocked by systemic NOS inhibition. These results indicate that the blockade of NOS activity significantly reduces the ability of BF stimulation to induce changes in the EEG pattern and suggest a role for NO in the BF-cholinergic system implicated in arousal mechanisms.
机译：一氧化氮（NO）与参与睡眠-觉醒周期调节的一些主要通路有关。一氧化氮合酶（NOS）在胆碱能的基础前脑（BF）细胞投射到皮质中的存在表明NO在唤醒过程中由BF诱导的激活中起作用。我们在麻醉的猫中测试了以下假设：抑制NOS会降低高炉胆碱能纤维诱导皮层激活的能力。在控制条件下，BF刺激引起了类似清醒的脑电图模式（即，低频-高振幅振荡活动的减少和高频-低振幅活动的增加）。阻断NOS活性后，强烈刺激BF刺激诱导皮质激活的能力。此外，伏安法测定的NO水平揭示了BF刺激后皮质NO的增加，也被全身性NOS抑制所阻断。这些结果表明，NOS活性的阻断显着降低了BF刺激诱导EEG模式改变的能力，并暗示了NO在与唤醒机制有关的BF胆碱能系统中的作用。

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