...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats.
【24h】

Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats.

机译：血清素1A受体激动剂可逆转脊髓损伤大鼠的呼吸异常。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Contusion spinal cord injury (SCI) at T8 produces respiratory abnormalities in conscious rats breathing room air and challenged with CO2. In seeking ways to improve respiration after SCI, we tested drugs that stimulate serotonin 1A (5-HT1A) receptors, based on our previous findings that these agents can counteract respiratory depression produced by morphine overdose. Respiratory function was measured with a head-out plethysmograph system in conscious rats. T8 SCI rats (n = 5) showed decreased tidal volume (Vt; 0.90 +/- 0.02-0.66 +/- 0.03 ml; p < 0.05) and increased respiratory rate (f;91 +/- 3.7-132 +/- 5.7 breaths/min; p < 0.05) with room air ventilation at 24 hr after injury. They also exhibited a diminished response to the respiratory stimulating effect of 7% CO2; minute ventilation increased to 250 +/- 17 ml/min before, but only to 162 +/- 15 ml/min at 24 hr after SCI (p < 0.05). Respiratory deficits during room air ventilation were also observed at 7 d after injury (n = 3). Treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylmino)tetralin (8-OH-DPAT; 250 microg/kg, i.p.) at 24 hr (n = 5) or 7 d (n = 3) after injury normalized Vt, f, and the respiratory response to 7% CO2. Identical results were obtained with another 5-HT1A receptor agonist, buspirone (1.5 mg/kg, i.p.; n = 3). In contrast, intraperitoneal saline vehicle administration (n = 5) showed no beneficial effects on SCI-impaired respiration. Finally, pretreatment with a specific antagonist of 5-HT1A receptors, 4-iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-benzamid e (3 mg/kg, i.p.; n = 3) given 20 min before 8-OH-DPAT, prevented 8-OH-DPAT from restoring respiration to normal. Our results demonstrate that drugs that stimulate 5-HT1A receptors counteract respiratory abnormalities in conscious rats after SCI.
机译：T8处的挫伤性脊髓损伤（SCI）在有意识的大鼠呼吸室内空气并受到CO2攻击时产生呼吸异常。在寻找改善SCI后呼吸的方法时，我们基于先前的发现这些药物可以抵消吗啡过量引起的呼吸抑制，对刺激血清素1A（5-HT1A）受体的药物进行了测试。用抬头体积描记器系统测量清醒大鼠的呼吸功能。 T8 SCI大鼠（n = 5）显示潮气量减少（Vt; 0.90 +/- 0.02-0.66 +/- 0.03 ml; p <0.05）和呼吸频率增加（f; 91 +/- 3.7-132 +/- 5.7呼吸/分钟; p <0.05），受伤后24小时室内通风。他们还对7％CO2的呼吸刺激作用表现出减弱的反应。每分钟通气量在SCI后24小时之前增加到250 +/- 17 ml / min，但在SCI后24小时仅增加到162 +/- 15 ml / min（p <0.05）。受伤后第7天（n = 3）也观察到室内空气流通期间的呼吸不足。在24小时（n = 5）或7天（n = 5）时，用5-HT1A受体激动剂8-羟基-2-（二-正丙基氨基）四氢化萘（8-OH-DPAT; 250 microg / kg，ip）处理3）受伤后Vt，f和对7％CO2的呼吸反应恢复正常。用另一种5-HT1A受体激动剂丁螺环酮（1.5mg / kg，腹膜内; n ＝ 3）获得了相同的结果。相比之下，腹膜内注射生理盐水（n = 5）对SCI受损的呼吸作用无益处。最后，使用5-HT1A受体特异性拮抗剂4-碘-N- [2- [4-（甲氧基苯基）-1-哌嗪基]乙基] -N-2-吡啶基-苯甲酰胺e（3 mg / kg， ip; n = 3）在8-OH-DPAT之前20分钟给予，阻止8-OH-DPAT恢复呼吸正常。我们的结果表明，刺激5-HT1A受体的药物可抵消SCI后清醒大鼠的呼吸道异常。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号