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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Decline of the critical period of visual plasticity is concurrent with the reduction of NR2B subunit of the synaptic NMDA receptor in layer 4.
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Decline of the critical period of visual plasticity is concurrent with the reduction of NR2B subunit of the synaptic NMDA receptor in layer 4.

机译：视觉可塑性的关键时期的下降与第4层中突触NMDA受体的NR2B亚单位的减少同时发生。

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摘要

The specific composition of NMDA receptor subunits is thought to underlie the developmental plasticity of the cortex revealed by unbalanced binocular stimulation. However, evidence that NR2 subunits change in correlation with the critical period at locations that are relevant to visual plasticity has been missing. Using preembedding and postembedding immunostaining, as well as electron microscopy, we quantified the volumetric densities of NR1-, NR2A-, and NR2B-containing synapses in layers 4 and 2/3 of the ferret visual cortex at different postnatal ages. Before eye opening, NR2A is encountered infrequently at postsynaptic sites in layer 4, but it increases sharply by postnatal day 34. In the subsequent weeks, postsynaptic NR2A labeling increases gradually in both layers 4 and 2/3 to become the most prevalent subunit in the adult animal. The NR2B subunit is the more prevalent subunit at the onset of the critical period of cortical plasticity. However, it displays different developmental patterns in layers 4 and 2/3. Although no change occurs in synaptic NR2B density in layer 2/3, in layer 4, NR2B maintains its high levels through the peak of the critical period and then becomes significantly reduced by the end of the peak of the critical period. This low level is maintained throughout adulthood. Our results demonstrate a correlation between the loss of NR2B subunits from layer 4 synaptic sites and the decline of the critical period, suggesting that the presence of NR2B subunits at synaptic sites could be a permissive factor regulating the ocular dominance plasticity of the developing cortex.
机译：NMDA受体亚基的特定组成被认为是由不平衡的双眼刺激揭示的皮质发育可塑性的基础。但是，缺少与视觉可塑性相关的位置上的关键时期相关的NR2亚基变化的证据。使用包埋前和包埋后免疫染色以及电子显微镜，我们对不同出生后雪貂视觉皮层的第4和2/3层中含有NR1，NR2A和NR2B突触的体积密度进行了定量。睁眼之前，在第4层的突触后部位很少见到NR2A，但在出生后第34天急剧增加。在随后的几周中，在第4层和第2/3层，突触后NR2A标记逐渐增加，成为NR2A中最普遍的亚基。成年动物。在皮质可塑性的关键时期开始时，NR2B亚基是更普遍的亚基。但是，它在第​​4层和第2/3层中显示出不同的发展模式。尽管第2/3层的突触NR2B密度没有变化，但在第4层中，NR2B在关键时段的峰值期间保持其高水平，然后在关键时段的峰值结束时显着降低。在整个成年期都保持这种低水平。我们的研究结果表明，第4层突触位点的NR2B亚基的丢失与临界期的下降之间存在相关性，这表明在突触位点的NR2B亚基的存在可能是调节发育中皮层的眼优势可塑性的允许因素。

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