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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Voltage-dependent switching of sensorimotor integration by a lobster central pattern generator.
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Voltage-dependent switching of sensorimotor integration by a lobster central pattern generator.

机译：通过龙虾中央模式生成器进行的取决于电压的感应电动机集成切换。

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摘要

Behavioral adaptations and the underlying neural plasticity may not simply result from peripheral information conveyed by sensory inputs. Central neuronal networks often spontaneously generate neuronal activity patterns that may also contribute to sensorimotor integration and behavioral adaptations. The present study explored a novel form of sensory-induced plasticity by which the resulting changes in motor output depend essentially on the preexisting functional state of an identified neuron of an endogenously active central network. In the isolated lobster stomatogastric nervous system, electrical stimulation of a mechanosensory nerve transiently inactivated rhythmic spike bursting in the lateral pyloric (LP) neuron of the pyloric motor pattern-generating network. Repeated sensory nerve stimulation gradually and long-lastingly strengthened the bursting of the LP neuron to the detriment of sensory-elicited inactivation. This strengthening of pyloric-timed rhythmic activity was enhanced by experimental depolarization of the neuron. Conversely, when the LP neuron was hyperpolarized, the same sensory stimulation paradigm now gradually increased the susceptibility of the pyloric-timed bursting of the network neuron to sensory-elicited inactivation. Modulation of depolarization-activated and hyperpolarization-activated ionic conductances that underlie the intrinsic bursting properties of the LP neuron may contribute via differential voltage-dependent recruitment and effects to the respective adaptive processes. These data therefore suggest a novel state-dependent mechanism by which an endogenously active central network can decrease or increase its responsiveness to the same sensory input.
机译：行为适应和潜在的神经可塑性可能不只是由感官输入传达的周围信息导致的。中枢神经元网络通常会自发生成神经元活动模式，这也可能有助于感觉运动整合和行为适应。本研究探索了一种新型的感觉诱发可塑性，通过该形式，运动输出的变化基本上取决于内源性活动​​中心网络的已识别神经元的预先存在的功能状态。在孤立的龙虾胃胃神经系统中，机械感应神经的电刺激使幽门运动模式生成网络的侧向幽门（LP）神经元中的节律性突波瞬时失活。反复反复的感觉神经刺激逐渐并持久地增强了LP神经元的爆发，从而损害了感觉诱发的失活。通过神经元的实验去极化增强了幽门定时节律活动的这种增强。相反，当LP神经元超极化时，相同的感觉刺激范例现在逐渐增加了网络神经元的幽门定时爆发对感觉诱发的失活的敏感性。 LP神经元的内在爆发特性基础的去极化激活和超极化激活离子电导的调制可能通过依赖于电压的募集和对各自的适应性过程的影响而起作用。因此，这些数据提出了一种新颖的状态相关机制，通过这种机制，内源性活动​​中心网络可以降低或增加其对相同感觉输入的响应。

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