...
首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Noradrenergic stimulation enhances human action monitoring.
【24h】

Noradrenergic stimulation enhances human action monitoring.

机译:去甲肾上腺素能刺激增强了人类行为监测。

获取原文
获取原文并翻译 | 示例
           

摘要

Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by event-related brain potentials, was examined. After the administration of a placebo or the selective alpha2-adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleus-noradrenaline system exerts a rather specific effect on human action monitoring.
机译:去甲肾上腺素能神经传递与前额叶皮层介导的更高认知功能的调节有关。在本研究中,研究了去甲肾上腺素能刺激对人类行为监测系统的影响,该事件以与事件相关的脑电势为指标。服用安慰剂或选择性α2-肾上腺素受体拮抗剂育亨宾(育亨宾)可刺激蓝斑中的烧灼和去甲肾上腺素释放后,从执行字母侧翼任务的健康志愿者处获得了脑电记录。育亨宾导致与错误相关的负值幅度增加,同时动作错误显着减少。反应时间没有变化,在同等或不一致试验,反应前冲突或通过误差后反应时间减慢来测量的误差后调整中,该药物均未修饰N2。目前的发现表明,蓝斑-去甲肾上腺素系统在人类行为监测中发挥了相当特殊的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号