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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Breakdown of long-range temporal correlations in theta oscillations in patients with major depressive disorder.
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Breakdown of long-range temporal correlations in theta oscillations in patients with major depressive disorder.

机译：重度抑郁症患者θ振荡的长期时间相关性分解。

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Neuroimaging has revealed robust large-scale patterns of high neuronal activity in the human brain in the classical eyes-closed wakeful rest condition, pointing to the presence of a baseline of sustained endogenous processing in the absence of stimulus-driven neuronal activity. This baseline state has been shown to differ in major depressive disorder. More recently, several studies have documented that despite having a complex temporal structure, baseline oscillatory activity is characterized by persistent autocorrelations for tens of seconds that are highly replicable within and across subjects. The functional significance of these long-range temporal correlations has remained unknown. We recorded neuromagnetic activity in patients with a major depressive disorder and in healthy control subjects during eyes-closed wakeful rest and quantified the long-range temporal correlations in the amplitude fluctuations of different frequency bands. We found that temporal correlations in the theta-frequency band (3-7 Hz) were almost absent in the 5-100 s time range in the patients but prominent in the control subjects. The magnitude of temporal correlations over the left temporocentral region predicted the severity of depression in the patients. These data indicate that long-range temporal correlations in theta oscillations are a salient characteristic of the healthy human brain and may have diagnostic potential in psychiatric disorders. We propose a link between the abnormal temporal structure of theta oscillations in the depressive patients and the systems-level impairments of limbic-cortical networks that have been identified in recent anatomical and functional studies of patients with major depressive disorder.
机译：神经影像学揭示了在经典的闭眼清醒休息条件下人脑中高强度神经元活动的大规模模式，这表明在没有刺激驱动的神经元活动的情况下存在持续的内源性加工的基线。已显示该基线状态在重度抑郁症中有所不同。最近，几项研究证明，尽管基线结构具有复杂的时间结构，但其基线振荡活动仍具有持续数十秒的持续自相关性，可在受试者体内和受试者之间高度复制。这些远程时间相关性的功能意义仍然未知。我们记录了重度抑郁症患者和健康对照组的闭眼清醒休息期间的神经磁活动，并量化了不同频段振幅波动的长期时间相关性。我们发现，在患者的5-100 s的时间范围内，theta频带（3-7 Hz）的时间相关性几乎不存在，而在对照组中则很明显。左颞中央区域的时间相关性大小可预测患者抑郁的严重程度。这些数据表明，theta振荡的长期时间相关性是健康人脑的显着特征，在精神疾病中可能具有诊断潜力。我们提出抑郁症患者theta振荡的异常时间结构与边缘性皮层网络的系统级损伤之间的联系，最近一次对重大抑郁症患者进行的解剖学和功能研究已经确定了该系统性损伤。

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