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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Multiple cell populations in the early postnatal subventricular zone take distinct migratory pathways: a dynamic study of glial and neuronal progenitor migration.
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Multiple cell populations in the early postnatal subventricular zone take distinct migratory pathways: a dynamic study of glial and neuronal progenitor migration.

机译：出生后脑室下带早期的多个细胞群采用不同的迁移途径：对神经胶质和神经元祖细胞迁移的动态研究。

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摘要

Neural progenitors in the subventricular zone (SVZ) of the postnatal rat forebrain give rise to either olfactory interneurons or glia. To investigate the overall patterns of progenitor movement, we labeled neonatal rat SVZ cells by stereotactic injection of a GFP-encoding retrovirus into the SVZ at various coronal levels. We then studied the movements of labeled cells by time-lapse videomicroscopy in living brain slices cut in different orientations. We observed two migration patterns: (1) progenitors migrated radially into the overlying white matter and cortex, but only at the level of viral injection; these were previously shown to give rise to astrocytes and oligodendrocytes, (2) progenitors migrated in a bidirectional, rostrocaudal pattern along the entire extent of the SVZ; many of these cells eventually migrated into the olfactory bulb and developed into interneurons, but they did not turn to migrate radially out of the SVZ until they reached the olfactory bulb. Video imaging showed apparent boundaries to migration between the SVZ and adjacent structures. These observations indicate that there are at least two distinct migratory pathways within the SVZ used differentially by immature neurons and glia.
机译：出生后大鼠前脑室下区（SVZ）的神经祖细胞产生嗅觉中神经元或神经胶质。为了研究祖细胞运动的总体模式，我们通过立体定向将编码GFP的逆转录病毒以不同的冠状水平注入SVZ来标记新生大鼠SVZ细胞。然后，我们通过延时视频显微镜研究了在不同方向切开的活脑切片中标记细胞的运动。我们观察到了两种迁移模式：（1）祖细胞径向迁移到上层白质和皮层，但仅在病毒注射水平迁移;这些以前被证明会产生星形胶质细胞和少突胶质细胞。（2）祖细胞在整个SVZ范围内以双向，头尾尾状模式迁移。这些细胞中的许多最终迁移到嗅球中并发育成中间神经元，但是直到它们到达嗅球时才转向放射状地从SVZ迁移出去。视频成像显示了SVZ与相邻结构之间迁移的明显边界。这些观察结果表明，SVZ内至少有两个不同的迁移途径，它们被未成熟的神经元和神经胶质细胞不同地使用。

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