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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Step response analysis of thermotaxis in Caenorhabditis elegans.
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Step response analysis of thermotaxis in Caenorhabditis elegans.

机译：秀丽隐杆线虫的趋热性的阶跃响应分析。

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摘要

The nematode Caenorhabditis elegans migrates toward a preferred temperature on a thermal gradient. A candidate neural network for thermotaxis in C. elegans has been identified, but the behavioral strategy implemented by this network is poorly understood. In this study, we tested whether thermal migration is achieved by modulating the probability of turning behavior, as in C. elegans chemotaxis. This was done by subjecting unrestrained wild-type, cryophilic, or thermophilic worms to rapid spatially uniform temperature steps (3 degrees C), up or down from the cultivation temperature. Each of the three types of worms we analyzed showed a different pair of responses to the two types of steps. Comparison of wild-type and mutant response patterns suggested a model in which thermal migration involves a unique response to the gradient depending on the orientation of the worm relative to its preferred temperature. Overall, however, turning probability was modulated in a manner consistent with a role for turningbehavior in thermal migration. Our results suggest that sensory systems for thermotaxis and chemotaxis may converge on a common behavioral mechanism.
机译：线虫秀丽隐杆线虫在热梯度上向优选温度迁移。秀丽隐杆线虫的趋热性的候选神经网络已被确定，但对该网络实现的行为策略了解甚少。在这项研究中，我们测试了是否通过调节线虫行为的可能性来实现热迁移，如秀丽隐杆线虫的趋化性。这是通过使不受限制的野生型，嗜冷性或嗜热性蠕虫经受比培养温度高或低的快速空间均匀温度步长（3摄氏度）来完成的。我们分析的三种类型的蠕虫中的每一种都显示出对两种类型步骤的不同响应。比较野生型和突变体响应模式，提出了一个模型，其中热迁移涉及对蠕虫的独特响应，具体取决于蠕虫相对于其首选温度的方向。但是，总的来说，转向概率的调整方式与热迁移中转向行为的作用相一致。我们的结果表明，趋热性和趋化性的感觉系统可能会收敛于一个共同的行为机制。

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