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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease.
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Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease.

机译：阿尔茨海默氏病的淀粉样蛋白前体蛋白23转基因小鼠模型中体感反应的年龄依赖性损伤。

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摘要

Quantitative functional magnetic resonance imaging was applied to characterize brain function in amyloid precursor protein 23 (APP23) transgenic mice, which reproduce the neuropathological alterations associated with Alzheimer's disease. Electrical stimulation of the paw led to cerebral blood volume increases in the contralateral somatosensory cortex. In APP23 mice this hemodynamic response decreased with increasing age of the animal and with increasing stimulus amplitude as compared with wild-type animals. The age-dependent dysfunction in APP23 mice may be attributed in part to a compromised cerebrovascular reactivity. Quantitative functional brain mapping that uses standardized sensory inputs should allow for assessment of disease progression and therapy response (e.g., passive immunization against beta-amyloid) in patients also.
机译：应用定量功能磁共振成像来表征淀粉样蛋白前体蛋白23（APP23）转基因小鼠的脑功能，该小鼠可重现与阿尔茨海默氏病相关的神经病理学改变。爪的电刺激导致对侧体感皮层的脑血容量增加。在APP23小鼠中，与野生型动物相比，该血液动力学响应随动物年龄的增加和刺激幅度的增加而降低。 APP23小鼠的年龄依赖性功能障碍可能部分归因于脑血管反应性受损。使用标准化的感觉输入的定量功能性脑图分析还应允许评估患者的疾病进展和治疗反应（例如，针对β淀粉样蛋白的被动免疫）。

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