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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate.
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Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate.

机译：非人类灵长类动物的运动皮层和前额叶皮层的小脑环。

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We used transneuronal transport of neurotropic viruses to examine the topographic organization of circuits linking the cerebellar cortex with the arm area of the primary motor cortex (M1) and with area 46 in dorsolateral prefrontal cortex of monkeys. Retrograde transneuronal transport of the CVS-11 (challenge virus strain 11) strain of rabies virus in cerebello-thalamocortical pathways revealed that the arm area of M1 receives input from Purkinje cells located primarily in lobules IV-VI of the cerebellar cortex. In contrast, transneuronal transport of rabies from area 46 revealed that it receives input from Purkinje cells located primarily in Crus II of the ansiform lobule. Thus, both M1 and area 46 are the targets of output from the cerebellar cortex. However, the output to each area of the cerebral cortex originates from Purkinje cells in different regions of the cerebellar cortex. Anterograde transneuronal transport of the H129 strain of herpes simplex virus type 1 (HSV1) revealed that neurons in the arm area of M1 project via the pons to granule cells primarily in lobules IV-VI, whereas neurons in area 46 project to granule cells primarily in Crus II. Together, the findings from rabies and HSV1 experiments indicate that the regions of the cerebellar cortex that receive input from M1 are the same as those that project to M1. Similarly, the regions of the cerebellar cortex that receive input from area 46 are the same as those that project to area 46. Thus, our observations suggest that multiple closed-loop circuits represent a fundamental architectural feature of cerebrocerebellar interactions.
机译：我们使用神经营养性病毒的跨神经元运输来检查连接小脑皮层与主要运动皮层（M1）的臂部区域以及猴子背外侧前额叶皮层区域46的回路的拓扑结构。狂犬病病毒CVS-11（挑战病毒11号株）在小脑-丘脑皮质途径中的逆行跨神经元转运显示，M1的臂区接受了主要位于小脑皮质小叶IV-VI中的Purkinje细胞的输入。相比之下，来自区域46的狂犬病的经神经元转运显示它接收了主要位于ansiform小叶Crus II中的Purkinje细胞的输入。因此，M1和区域46都是小脑皮层输出的目标。但是，大脑皮层每个区域的输出均来自小脑皮层不同区域中的浦肯野细胞。单纯疱疹病毒1型（HSV1）的H129菌株的顺行经神经元转运显示，M1臂区的神经元主要通过小叶IV-VI中的颗粒细胞通过脑桥投射，而46区中的神经元则主要通过小叶IV-VI投射到颗粒细胞。 Crus II。总之，狂犬病和HSV1实验的结果表明，从M1接收输入的小脑皮层区域与投射到M1的区域相同。类似地，从区域46接收输入的小脑皮质区域与投射到区域46的区域相同。因此，我们的观察结果表明，多个闭环回路代表了小脑与大脑相互作用的基本结构特征。

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