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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Dynamic interaction of oscillatory neurons coupled with reciprocally inhibitory synapses acts to stabilize the rhythm period.
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Dynamic interaction of oscillatory neurons coupled with reciprocally inhibitory synapses acts to stabilize the rhythm period.

机译：振荡神经元与相互作用的抑制性突触的动态相互作用可稳定节律周期。

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摘要

In the rhythmically active pyloric circuit of the spiny lobster, the pyloric dilator (PD) neurons are members of the pacemaker group of neurons that make inhibitory synapses onto the follower lateral pyloric (LP) neuron. The LP neuron, in turn, makes a depressing inhibitory synapse to the PD neurons, providing the sole inhibitory feedback from the pyloric network to its pacemakers. This study investigates the dynamic interaction between the pyloric cycle period, the two types of neurons, and the feedback synapse in biologically realistic conditions. When the rhythm period was changed, the membrane potential waveform of the LP neuron was affected with a consistent pattern. These changes in the LP neuron waveform directly affected the dynamics of the LP to PD synapse and caused the postsynaptic potential (PSP) in the PD neurons to both peak earlier in phase and become larger in amplitude. Using an artificial synapse implemented in dynamic clamp, we show that when the LP to PD PSP occurred early in phase,it acted to speed up the pyloric rhythm, and larger PSPs also strengthened this trend. Together, these results indicate that interactions between these two types of neurons can dynamically change in response to increases in the rhythm period, and this dynamic change provides a negative feedback to the pacemaker group that could work to stabilize the rhythm period.
机译：在有刺龙虾的节律性活动性幽门回路中，幽门扩张器（PD）神经元是起搏器组神经元的成员，这些神经元在突触外侧幽门（LP）神经元上产生抑制性突触。 LP神经元反过来对PD神经元产生抑制性突触，从而将幽门神经网络的唯一抑制反馈提供给其起搏器。这项研究调查了幽灵循环周期，两种类型的神经元和在生物现实条件下的反馈突触之间的动态相互作用。当节律周期改变时，LP神经元的膜电位波形以一致的模式受到影响。 LP神经元波形中的这些变化直接影响LP到PD突触的动力学，并导致PD神经元中的突触后电位（PSP）既在相位上达到峰值，又在振幅上变大。使用在动态钳制中实现的人工突触，我们发现当LP到PD的PSP发生在早期时，它起到加速幽门节律的作用，而较大的PSP也加强了这种趋势。在一起，这些结果表明，这两种类型的神经元之间的相互作用可以响应于节律周期的增加而动态变化，并且这种动态变化为起搏器组提供了负反馈，可以起到稳定节律周期的作用。

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