...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients.
【24h】

Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients.

机译：视觉引导的运动可抑制帕金森氏病患者的丘脑底振荡。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is considerable evidence that abnormal oscillatory activity in the basal ganglia contributes to the pathogenesis of Parkinson's disease. However, little is known regarding the relationship of oscillations to volitional movements. Our goal was to evaluate the dynamics of oscillatory activity at rest and during movement. We performed microelectrode recordings from the subthalamic nucleus (STN) of patients undergoing deep brain stimulation surgery. During recordings, the patients used a joystick to guide a cursor to one of four targets on a monitor. We recorded 184 cells and 47 pairs of cells in 11 patients. At rest, 26 cells (14%) demonstrated significant oscillatory activity, with a mean frequency of 18 Hz. During movement, this oscillatory activity was either reduced or completely abolished in all of the cells. At rest, 18 pairs (38%) of cells in five patients exhibited synchronized oscillatory activity, with a mean frequency of 15 Hz. In 17 of the 18 pairs, both of the cells exhibited oscillations, and, in one pair, only one of the cells was oscillatory. These synchronized oscillations were also significantly decreased with movement. There was a strong inverse correlation between firing rates and oscillatory activity. As the firing rates increased with movement, there was a decrease in oscillatory activity. These findings suggest that visually guided movements are associated with a dampening and desynchronization of oscillatory activity in STN neurons. One possible explanation for these observations is that the increased cortical drive associated with movement preparation and execution leads to a transient dampening of STN oscillations, hence facilitating movement.
机译：有大量证据表明，基底神经节的异常振荡活动是帕金森氏病的发病机理。但是，关于振动与自主运动的关系知之甚少。我们的目标是评估静止和运动过程中振动活动的动力学。我们对进行深部脑刺激手术的患者的丘脑底核（STN）进行了微电极记录。在记录过程中，患者使用操纵杆将光标引导到监视器上的四个目标之一。我们记录了11例患者中的184个细胞和47对细胞。静止时，有26个细胞（占14％）表现出明显的振荡活动，平均频率为18 Hz。在运动过程中，这种振荡活动在所有细胞中都减少了或完全消失了。休息时，五名患者中的18对细胞（38％）表现出同步的振荡活动，平均频率为15 Hz。在18对中的17对中，两个单元均表现出振荡，并且在一对中，只有一个单元具有振荡性。这些同步的振动也随着运动而显着降低。射速和振荡活动之间存在很强的负相关。随着射击速率随着运动的增加而增加，振荡活动减少。这些发现表明视觉引导的运动与STN神经元的振荡活动的减弱和失步有关。对于这些观察结果的一种可能解释是，与运动准备和执行相关的皮质运动的增加导致STN振荡的暂时衰减，从而促进了运动。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号