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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Initiation, propagation, and termination of epileptiform activity in rodent neocortex in vitro involve distinct mechanisms.
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Initiation, propagation, and termination of epileptiform activity in rodent neocortex in vitro involve distinct mechanisms.

机译：啮齿类动物新皮层体外癫痫样活动的启动，传播和终止涉及不同的机制。

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摘要

Waves of epileptiform activity in neocortex have three phenomenological stages: initiation, propagation, and termination. We use a well studied model of epileptiform activity in vitro to investigate directly the hypothesis that each stage is governed by an independent mechanism within the underlying cortical circuit. Using the partially disinhibited neocortical slice preparation, activity is induced and modulated using neurotransmitter receptor antagonists and is measured using both intracellular recordings and a linear array of extracellular electrodes. We find that initiation depends on both synaptic excitation and inhibition and entails a slow process of recruitment at discrete spatial locations within cortical layer 5 but not layer 2/3. Propagation depends on synaptic excitation but not inhibition and is a fast process that involves neurons across the spatial extent of the slice and in all cortical layers. Termination is modulated by synaptic excitation and inhibition. In space, termination occurs reliably at discrete locations. In time, termination is characterized by a strong depolarizing shift (block) and recovery of neurons in all cortical layers. These results suggest that the phenomenological stages of epileptiform events correspond to distinct mechanistic stages.
机译：新皮层中的癫痫样活动波具有三个现象学阶段：起始，传播和终止。我们使用体外研究好的癫痫样活动模型来直接研究以下假设：每个阶段均由底层皮层回路内的独立机制控制。使用部分抑制的新皮层切片制剂，使用神经递质受体拮抗剂诱导和调节活性，并使用细胞内记录和细胞外电极的线性阵列进行测量。我们发现，启动依赖于突触激发和抑制，并且在皮层第5层而不是第2/3层的离散空间位置需要缓慢的募集过程。传播取决于突触兴奋而不是抑制，并且是一个快速的过程，涉及整个切片的空间范围以及所有皮质层中的神经元。终止通过突触激发和抑制来调节。在太空中，端接可靠地发生在离散的位置。随着时间的流逝，终止的特征是所有皮质层中神经元的强烈去极化移位（阻滞）和恢复。这些结果表明癫痫样事件的现象学阶段对应于不同的机制阶段。

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