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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.
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Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.

机译：苔藓纤维反复发作会在癫痫大鼠的颗粒细胞上建立异常的海藻酸酯受体操纵性突触。

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摘要

Glutamatergic mossy fibers of the hippocampus sprout in temporal lobe epilepsy and establish aberrant synapses on granule cells from which they originate. There is currently no evidence for the activation of kainate receptors (KARs) at recurrent mossy fiber synapses in epileptic animals, despite their important role at control mossy fiber synapses. We report that KARs are involved in ongoing glutamatergic transmission in granule cells from chronic epileptic but not control animals. KARs provide a substantial component of glutamatergic activity, because they support half of the non-NMDA receptor-mediated excitatory drive in these cells. KAR-mediated EPSC(KA)s are selectively generated by recurrent mossy fiber inputs and have a slower kinetics than EPSC(AMPA). Therefore, in addition to axonal rewiring, sprouting of mossy fibers induces a shift in the nature of glutamatergic transmission in granule cells that may contribute to the physiopathology of the dentate gyrus in epileptic animals.
机译：海马的谷氨酸能苔藓纤维在颞叶癫痫中萌发，并在它们起源的颗粒细胞上建立异常突触。尽管癫痫动物在控制苔藓纤维突触中起重要作用，但目前尚无证据表明其在反复发作的苔藓纤维突触中会激活红藻氨酸受体（KARs）。我们报告说，KARs参与了来自慢性癫痫动物而非对照动物的颗粒细胞中正在进行的谷氨酸能传递。 KAR提供了谷氨酸能活性的重要组成部分，因为它们支持这些细胞中非NMDA受体介导的兴奋性驱动的一半。 KAR介导的EPSC（KA）是由回生的苔藓纤维输入选择性产生的，并且动力学比EPSC（AMPA）慢。因此，除了轴突重新布线之外，长满苔藓的纤维的萌发还引起颗粒细胞中谷氨酸能传递性质的改变，这可能有助于癫痫动物齿状回的生理病理。

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