Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.

Khazipov R; Holmes GL

首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.

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Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.

机译：在体内，通过GABA能抑制海藻酸盐诱导的癫痫活动同步。

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We studied cellular mechanisms of synchronization of epileptiform activity induced by kainic acid in a novel preparation of superfused rat hippocampus in vivo. Under urethane anesthesia, kainate induced epileptic population spikes occurring at 30-40 Hz. Pyramidal cells fired exclusively during population spikes with an average probability of 0.34 on rebound of rhythmic GABA(A)-mediated inhibitory postsynaptic events. Excitatory synaptic events contributed little to seizure activity. Rhythmic epileptiform activity was suppressed by blocking GABA(A) receptors and was slowed by barbiturates. Thus, GABAergic inhibition is instrumental in synchronizing kainate-induced epileptiform rhythmic activity in the gamma frequency band in the intact hippocampus in vivo.

机译：我们研究了海藻酸诱导的癫痫样海马体新型制剂体内同步化癫痫样活动同步化的细胞机制。在氨基甲酸乙酯麻醉下，红藻氨酸盐引起的癫痫发作高峰在30-40 Hz发生。金字塔形细胞仅在种群高峰期间发射，其有节奏的GABA（A）介导的抑制性突触后事件反弹的平均概率为0.34。兴奋性突触事件对癫痫发作活动的贡献很小。节律性癫痫样活动被阻断GABA（A）受体抑制，并被巴比妥类药物减慢。因此，GABA能抑制在体内完整海马体的γ频段同步海藻酸盐诱导的癫痫样节律性活动中起重要作用。

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《The Journal of Neuroscience: The Official Journal of the Society for Neuroscience》 |2003年第12期|共5页
作者
Khazipov R; Holmes GL;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Epilepsy; Hippocampus; Kainic Acid; Neural Inhibition; gamma-Aminobutyric Acid; 癫痫; 海马; 红藻氨酸; 神经抑制;

机译：Epilepsy;Hippocampus;Kainic Acid;Neural Inhibition;gamma-Aminobutyric Acid;癫痫;海马;红藻氨酸;神经抑制;

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专利

1. 脑室注射GABA对小鼠盐酸诱导型胃溃疡的抑制效应 [J] . 徐项桂, 朱长生动物学报 . 1995,第003期
2. Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo. [J] . Khazipov R, Holmes GL The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第12期

机译：在体内，通过GABA能抑制海藻酸盐诱导的癫痫活动同步。
3. Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering [J] . Nakao Akito, Miki Takafumi, Shimono Ken, Pfluegers Archiv: European Journal of Physiology . 2015,第4期

机译：Gabaergic抑制的损害成熟是癫痫CA2 +通道突变小鼠的海马中的异常网络活性，缠扰
4. Effects of selective serotonin reuptake inhibitors on GABAergic inhibition in the hippocampus of normal and pilocarpine induced epileptic rats. [J] . Choi HC, Kim YI, Song HK, Brain research . 2010,第Null期

机译：选择性5-羟色胺再摄取抑制剂对正常和毛果芸香碱诱发的癫痫大鼠海马中GABA能抑制的影响。
5. EEG analysis reveals reduced seizure activity by optogenetic inhibition of GABAergic interneurons [C] . Qing Wu, Ben Foote-Huth, Stephan Steidl, 2017 IEEE International Conference on Systems, Man, and Cybernetics . 2017

机译：脑电图分析表明，通过光遗传抑制GABA能的中间神经元，降低了癫痫发作的活动
6. Ethanol excites synchronized neuronal network activity in the immature hippocampus via an increase in GABA release: Implications for fetal alcohol spectrum disorder. [D] . Galindo, Rafael. 2005

机译：乙醇通过增加GABA的释放来激发未成熟海马中同步的神经元网络活动：对胎儿酒精频谱异常的影响。
7. Synchronization of Kainate-Induced Epileptic Activity via GABAergic Inhibition in the Superfused Rat Hippocampus In Vivo [O] . Roustem Khazipov, Gregory L. Holmes 2003

机译：海藻酸酯诱导的过度融合的大鼠海马体内通过GABA能抑制的癫痫活动。
8. Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats [O] . Silva Ana P., Xapelli Sara, Pinheiro Paulo S., 2005

机译：海藻酸盐诱导的癫痫大鼠海马神经肽Y水平上调并通过神经肽Y受体调节谷氨酸释放

Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.

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