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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Identification and characterization of heterogeneous neuronal injury and death in regions of diffuse brain injury: evidence for multiple independent injury phenotypes.
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Identification and characterization of heterogeneous neuronal injury and death in regions of diffuse brain injury: evidence for multiple independent injury phenotypes.

机译：弥散性脑损伤区域的异质性神经元损伤和死亡的鉴定和表征：多种独立损伤表型的证据。

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Diffuse brain injury (DBI) is a consequence of traumatic brain injury evoked via rapid acceleration-deceleration of the cranium, giving rise to subtle pathological changes appreciated best at the microscopic level. DBI is believed to be comprised by diffuse axonal injury and other forms of diffuse vascular change. The potential, however, that the same forces can also directly injure neuronal somata in vivo has not been considered. Recently, while investigating DBI-mediated perisomatic axonal injury, we identified scattered, rapid neuronal somatic necrosis occurring within the same domains. Moving on the premise that these cells sustained direct somatic injury as a result of DBI, we initiated the current study, in which rats were intracerebroventricularly infused with various high-molecular weight tracers (HMWTs) to identify injury-induced neuronal somatic plasmalemmal disruption. These studies revealed that DBI caused immediate, scattered neuronal somatic plasmalemmal injury to all of the extracellularHMWTs used. Through this approach, a spectrum of neuronal change was observed, ranging from rapid necrosis of the tracer-laden neurons to little or no pathological change at the light and electron microscopic level. Parallel double and triple studies using markers of neuronal degeneration, stress, and axonal injury identified additional injured neuronal phenotypes arising in close proximity to, but independent of, neurons demonstrating plasmalemmal disruption. These findings reveal that direct neuronal somatic injury is a component of DBI, and diffuse trauma elicits a heretofore-unrecognized multifaceted neuronal pathological change within the CNS, generating heterogeneous injury and reactive alteration within both axons and neuronal somata in the same domains.
机译：弥漫性脑损伤（DBI）是颅骨快速加速或减速引起的颅脑外伤的结果，引起细微的病理变化，在微观水平上最好。据信DBI包括弥漫性轴索损伤和其他形式的弥散性血管改变。然而，尚未考虑相同的力也可以在体内直接伤害神经元躯体的可能性。最近，在调查DBI介导的周围性轴突损伤时，我们发现了在同一域内发生的散布的快速神经元体细胞坏死。在假定这些细胞由于DBI而遭受直接的躯体损伤的前提下，我们启动了当前的研究，在该研究中，大鼠脑室内注入了各种高分子量示踪剂（HMWT），以鉴定损伤引起的神经元体细胞质破坏。这些研究表明，DBI对使用的所有细胞外HMWT造成了直接的，分散的神经元体质膜损伤。通过这种方法，观察到了神经元变化的频谱，范围从充满示踪剂的神经元快速坏死到在光和电子显微镜下几乎没有病理变化。使用神经元变性，压力和轴突损伤标志物进行的平行双倍和三重研究确定了额外的受损神经元表型，这些表型与显示质膜破坏的神经元非常接近，但彼此独立。这些发现表明，直接的神经元躯体损伤是DBI的一个组成部分，弥漫性创伤引起CNS内迄今为止未被认识的多方面神经元病理改变，从而在同一域的轴突和神经元躯体内产生异质性损伤和反应性改变。

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