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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >A novel RNA-binding protein in neuronal RNA granules: regulatory machinery for local translation.
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A novel RNA-binding protein in neuronal RNA granules: regulatory machinery for local translation.

机译：神经元RNA颗粒中的一种新型RNA结合蛋白：用于本地翻译的调控机制。

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Local translation in neuronal dendrites is an important basis for long-term synaptic plasticity, and RNA granules in the dendrites are involved in the local translation. Here, we identify RNG105 (RNA granule protein 105), a novel RNA-binding protein, as a component of the RNA granules in dendrites of hippocampal neurons. The RNG105-localizing RNA granules contain mRNAs, the translational products of which play key roles in synaptic plasticity. RNG105 has an ability to repress translation both in vitro and in vivo, consistent with the finding that the RNA granule is translationally arrested in the basal conditions. Dissociation of RNG105 from the RNA granules is induced by BDNF, a growth factor responsible for synaptic plasticity. The RNG105 dissociation is coincident with the induction of local translation near the granules. These findings suggest that RNG105 is a translational repressor in the RNA granules and provide insight into the link between RNG105 dynamics and local translational regulation.
机译：神经元树突中的局部翻译是长期突触可塑性的重要基础，并且树突中的RNA颗粒参与局部翻译。在这里，我们确定RNG105（RNA颗粒蛋白105），一种新型的RNA结合蛋白，作为海马神经元树突中RNA颗粒的组成部分。 RNG105定位的RNA颗粒包含mRNA，其翻译产物在突触可塑性中起关键作用。 RNG105具有在体外和体内阻抑翻译的能力，这与发现RNA颗粒在基础条件下被翻译阻滞的发现一致。 RNG105从RNA颗粒中解离是由BDNF引起的，BDNF是负责突触可塑性的生长因子。 RNG105的解离与颗粒附近局部翻译的诱导相吻合。这些发现表明，RNG105是RNA颗粒中的翻译阻遏物，可深入了解RNG105动力学与局部翻译调控之间的联系。

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