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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Evidence for brainstem and supra-brainstem contributions to rapid cortical plasticity in adult monkeys.
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Evidence for brainstem and supra-brainstem contributions to rapid cortical plasticity in adult monkeys.

机译：有证据表明成年猴子的脑干和超脑干对快速皮层可塑性有贡献。

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摘要

Cortical maps can undergo amazingly rapid changes after injury of the body. These changes involve functional alterations in normal substrates, but the cortical and/or subcortical location(s) of these alterations, and the relationships of alterations in different substrates, remain controversial. The present study used neurophysiological approaches in adult monkeys to evaluate how brainstem organization of tactile inputs in the cuneate nucleus (CN) changes after acute injury of hand nerves. These data were then compared with analogous data from our earlier cortical area 3b studies, which used the same approaches and acute injury, to assess relationships of cuneate and cortical changes. The results indicate that cuneate tactile responsiveness, receptive field locations, somatotopic organization, and spatial properties of representations (i.e., location, continuity, size) change during the first minutes to hours after injury. The comparisons of cuneate and area 3b organization further show that some cuneate changes are preserved in area 3b, whereas other cuneate changes are transformed before being expressed in area 3b. The findings provide evidence that rapid reorganization in area 3b, in part, reflects mechanisms that operate from a distance in the cuneate nucleus and, in part, reflects supracuneate mechanisms that modify brainstem changes.
机译：身体受伤后，皮质图可能会发生惊人的快速变化。这些改变涉及正常基质中的功能改变，但是这些改变的皮质和/或皮质下位置以及不同基质中改变的关系仍然存在争议。本研究使用成年猴子的神经生理学方法评估手神经急性损伤后楔形核（CN）的触觉输入的脑干组织如何变化。然后将这些数据与我们之前的皮质区域3b研究的类似数据进行比较，该研究使用相同的方法和急性损伤来评估楔形骨和皮质变化的关系。结果表明，楔形触觉反应性，感受野位置，躯体组织和表征的空间特性（即位置，连续性，大小）在受伤后的前几分钟到几小时内发生变化。楔形和3b区域组织的比较进一步表明，一些楔形变化保留在区域3b中，而其他楔形变化则在区域3b中表达之前被转换。这些发现提供了证据，证明3b区的快速重组部分反映了在楔形核中远距离起作用的机制，部分反映了修饰脑干变化的超机制。

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