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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction.
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Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction.

机译：伏隔核中谷氨酸的传播介导可卡因成瘾的复发。

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摘要

Elevated dopamine transmission in the nucleus accumbens is thought to be a primary mediator of addiction to cocaine. However, repeated exposure to cocaine is associated with the recruitment of glutamate transmission. This poses the possibility that the behaviors characterizing cocaine addiction, such as craving-induced relapse, may not be preferentially mediated by dopamine transmission. An animal model of relapse was used to demonstrate that glutamate, and not dopamine transmission in the nucleus accumbens, is a primary mediator of cocaine-induced reinstatement of drug-seeking behavior. Reinstatement was produced by a systemic injection of cocaine or by the microinjection of the glutamate receptor agonist AMPA or dopamine into the nucleus accumbens. It was found that microinjection of an AMPA receptor antagonist into the nucleus accumbens blocked reinstatement by all compounds, whereas a dopamine receptor antagonist was effective only in blocking reinstatement by intra-accumbens dopamine administration. These data suggest an important role for nucleus accumbens glutamate and not dopamine transmission in cocaine-induced relapse to drug-seeking behavior.
机译：多巴胺在伏隔核中的传递增加被认为是可卡因成瘾的主要介质。然而，反复接触可卡因与谷氨酸传播的募集有关。这带来了一种可能性，即可卡因成瘾的行为，例如渴望诱发的复发，可能不会优先通过多巴胺传播来介导。复发的动物模型用来证明谷氨酸而不是多巴胺在伏隔核中的传播是可卡因诱导的寻求药物行为恢复的主要介质。通过全身注射可卡因或将谷氨酸受体激动剂AMPA或多巴胺微注射到伏隔核中，即可恢复原状。发现将AMPA受体拮抗剂微注射到伏隔核中可以阻止所有化合物的恢复，而多巴胺受体拮抗剂仅在通过伏隔内多巴胺给药来阻止恢复中有效。这些数据表明在可卡因诱导的寻药行为复发中伏隔核谷氨酸而不是多巴胺传递起重要作用。

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