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首页> 外文期刊>The Journal of Nuclear Medicine >Differential diagnosis of Parkinson's disease and vascular parkinsonism by (99m)Tc-TRODAT-1.
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Differential diagnosis of Parkinson's disease and vascular parkinsonism by (99m)Tc-TRODAT-1.

机译：（99m）Tc-TRODAT-1鉴别诊断帕金森氏病和血管性帕金森病。

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The aim of this study was to use brain SPECT to differentiate vascular parkinsonism (VP) from Parkinson's disease. METHODS: Fourteen VP patients (age range, 59-87 y; mean age, 70 +/- 7.5 y), 30 Parkinson's disease patients (age range, 54-84 y; mean age, 65 +/- 8.8 y), and 26 healthy (control) individuals (age range, 50-85 y; mean age, 60 +/- 9 y) were examined. A 925-MBq (25 mCi) dose of (99m)Tc-TRODAT-1 was injected intravenously, and brain SPECT images were acquired 4 h after injection. The ratio of specific to nonspecific striatal (99m)Tc-TRODAT-1 binding was measured and compared. RESULTS: After a region-of-interest analysis of the images from VP patients, Parkinson's disease patients, and healthy volunteers was performed to obtain ratios of putamen to occipital and striatal to occipital binding as a measurement of specific binding to the dopamine transporters in these regions of the brain, where dopamine neurons are concentrated, the specific binding in the 14 VP patients was slightly lower than but not statistically different from that of the healthy individuals in both putamen and caudate areas. A significant decrease in uptake of (99m)Tc-TRODAT-1 in the striatum (P<0.01) was found in Parkinson's disease patients. Reduction of the uptake was more pronounced in the contralateral putamen of Parkinson's disease patients than that of VP patients (P<0.001). A significant bilateral striatal asymmetry was also observed in Parkinson's disease patients but not in VP patients (P< 0.01). CONCLUSION: Our findings clearly show that, for VP patients, (99m)Tc-TRODAT-1 SPECT is a reliable method to differentiate VP from Parkinson's disease. Further studies, including those to differentiate Parkinson's disease from arteriosclerotic parkinsonism and patients with both VP and Parkinson's disease, are needed to help rule out the possibility of Parkinson's disease as early as possible.
机译：这项研究的目的是利用脑SPECT来区分血管帕金森病（VP）与帕金森氏病。方法：14名VP患者（年龄范围为59-87岁;平均年龄为70 +/- 7.5岁），30名帕金森氏病患者（年龄范围为54-84岁;平均年龄为65 +/- 8.8岁）和检查了26位健康（对照）个体（年龄范围：50-85岁;平均年龄：60 +/- 9岁）。静脉注射（99m）Tc-TRODAT-1 925 MBq（25 mCi）剂量，注射后4 h获得脑SPECT图像。测量并比较特异性与非特异性纹状体（99m）Tc-TRODAT-1结合的比率。结果：在对来自VP患者，帕金森氏病患者和健康志愿者的图像进行了感兴趣的区域分析之后，进行了壳壳与枕骨和纹状体与枕骨结合的比率的测量，以测量这些受试者与多巴胺转运蛋白的特异性结合。在多巴胺神经元集中的大脑区域，这14例VP患者的特异性结合略低于壳核和尾状区中健康个体的特异性结合，但在统计学上没有差异。在帕金森氏病患者中，纹状体对（99m）Tc-TRODAT-1的摄取显着降低（P <0.01）。与VP患者相比，帕金森氏病患者对侧壳核摄取的减少更为明显（P <0.001）。在帕金森氏病患者中也观察到明显的双侧纹状体不对称性，而在VP患者中则没有（P <0.01）。结论：我们的发现清楚地表明，对于VP患者，（99m）Tc-TRODAT-1 SPECT是区分VP与帕金森氏病的可靠方法。需要进行进一步的研究，包括区分帕金森氏病和动脉硬化性帕金森氏症以及VP和帕金森氏病的患者，以尽早排除帕金森氏病的可能性。

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