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首页> 外文期刊>The Journal of Nuclear Medicine >Subcortical aphasia after striatocapsular infarction: quantitative analysis of brain perfusion SPECT using statistical parametric mapping and a statistical probabilistic anatomic map.
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Subcortical aphasia after striatocapsular infarction: quantitative analysis of brain perfusion SPECT using statistical parametric mapping and a statistical probabilistic anatomic map.

机译：纹状体囊梗塞后皮层下失语：使用统计参数映射和统计概率解剖图对脑灌注SPECT进行定量分析。

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This study examined the relationship between the severity of aphasia and regional cerebral perfusion on brain SPECT using statistical parametric mapping (SPM) and a statistical probabilistic anatomic map (SPAM) in patients with a striatocapsular infarction (SCI) along with the other clinical and imaging findings. METHODS: The subjects were 16 right-handed Korean-speaking patients with a left SCI who underwent 99mTc-ethylcyteinate dimer (99mTc-ECD) SPECT (8.1 +/- 4.8 d [mean +/- SD] after onset). MRI showed that no patient had any abnormality in the cerebral cortex (6.8 +/- 6.0 d after onset). The aphasia quotient (AQ), which is a measure of the severity of aphasia, was obtained by using the Korean version of the Western Aphasia Battery (5.3 +/- 3.9 d after onset). For quantitative evaluation of cerebral perfusion, the asymmetry indices (AIs) for subcortical and cortical areas were calculated using SPM and SPAM. The infarct size was measured using MRI. RESULTS: Aphasia occurred in 15 (2 global, 7 transcortical, and 6 anomic aphasia) of the 16 patients. Left cerebral cortical hypoperfusion was observed in all 15 patients with subcortical aphasia. Aphasia was more severe in 6 patients with extensive cerebral cortical hypoperfusion than in the remaining 10 patients (AQ = 41.8 +/- 25.2 points vs. 84.2 +/- 7.7 points [mean +/- SD], P = 0.001). There was an association between the AQ and age (rho = -0.665), infarct size (rho = -0.594), AIs of the frontal cortex (rho = -0.653), temporal cortex (rho = -0.782), parietal cortex (rho = -0.694), whole cerebral cortex (rho = -0.768), and the cerebellar cortex (rho = 0.765). Voxel-based SPM analysis showed a significant positive correlation between the AQ and the perfusion of the left temporal cortex and the right cerebellum. CONCLUSION: The severity of subcortical aphasia after a left SCI without cortical abnormalities on MRI is associated with the extent and severity of the left cerebral cortical hypoperfusion on brain perfusion SPECT performed during the subacute stage, particularly in the left temporal cortex. Quantitative brain perfusion SPECT using SPM and SPAM can help in evaluating subcortical aphasia in a SCI because it provides functional information that cannot be obtained by morphologic imaging.
机译：这项研究使用统计参数映射（SPM）和统计概率解剖图（SPAM）检查了纹状体囊梗塞（SCI）患者失语的严重程度与脑SPECT上局部脑灌注之间的关系以及其他临床和影像学发现。方法：受试者为16名右撇子右韩语患者，左SCI接受99mTc-乙基胞嘧啶二聚体（99mTc-ECD）SPECT（发病后8.1 +/- 4.8 d [平均+/- SD]）。 MRI显示没有患者大脑皮层有任何异常（发病后6.8 +/- 6.0 d）。通过使用韩语版的“失语症西部电池”（发病后5.3 +/- 3.9 d）获得失语症商（AQ），它是衡量失语严重程度的指标。为了定量评估脑灌注，使用SPM和SPAM计算了皮质下和皮质区域的不对称指数（AIs）。使用MRI测量梗塞面积。结果：16例患者中有15例失语（2例，7例经皮层失语和6例失语）。 15例皮质下失语症患者均观察到左脑皮质灌注不足。与其余10例患者相比，6例广泛性大脑皮质灌注不足的患者失语症更为严重（AQ = 41.8 +/- 25.2点vs. 84.2 +/- 7.7点[平均值+/- SD]，P = 0.001）。 AQ和年龄（rho = -0.665），梗死面积（rho = -0.594），额叶皮层的AI（rho = -0.653），颞叶皮层（rho = -0.782），顶叶皮层（rho）之间存在关联= -0.694），整个大脑皮层（rho = -0.768）和小脑皮层（rho = 0.765）。基于体素的SPM分析显示AQ与左颞皮层和右小脑的灌注之间显着正相关。结论MRI上没有皮质异常的左SCI后皮层下失语的严重程度与亚急性期尤其是在左颞皮层进行脑灌注SPECT时左脑皮质灌注不足的程度和严重程度有关。使用SPM和SPAM的定量脑灌注SPECT可以帮助评估SCI中的皮层下失语，因为它提供了形态成像无法获得的功能信息。

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