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首页> 外文期刊>The Journal of otolaryngology >Radiation-induced soft tissue sarcomas of the head and neck.
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Radiation-induced soft tissue sarcomas of the head and neck.

机译：辐射诱发的头颈部软组织肉瘤。

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PURPOSE: To describe the occurrence of radiation-induced soft tissue sarcomas in a retrospectively analyzed cohort of patients. To analyze the histologic subtypes and survival in this rare disease. PATIENTS AND METHODS: While performing a retrospective analysis of soft tissue sarcomas in patients treated between 1974 and 1999 at the two major cancer centres in Alberta (Canada), eight patients presenting with nine sarcomas occurring in a previously radiated site were identified. Eight fulfilled the criteria for radiation-induced sarcoma. RESULTS: Radiation-induced sarcomas occurred between 10 months and more than 50 years after irradiation (median 7.35 years). Patients' ages ranged from 36 to 88 years (median 77.3 years) at the time of their sarcoma diagnosis. Histologically, four malignant fibrous histiocytomas, two dermatofibrosarcoma protuberans, two carcinosarcomas, and one fibrosarcoma were diagnosed. All patients received surgery as the primary treatment. Complete resection could not be achieved in three cases. Two of them died of disease. The 5-year disease-specific survival rate was 50%, whereas the 5-year overall survival rate was 25%. CONCLUSIONS: Radiotherapy can induce malignancies after a latency period of a few months to several years. Radiation-induced sarcomas are associated with poor overall prognosis. The treatment in most cases is late and ineffective. The population at risk for the development of radiation-induced sarcoma is increasing, so vigilance is required in the follow-up of those patients.
机译：目的：描述在回顾性分析的患者队列中辐射诱发的软组织肉瘤的发生情况。分析这种罕见疾病的组织学亚型和存活率。病人和方法：在对艾伯塔省（加拿大）的两个主要癌症中心在1974年至1999年间接受治疗的患者的软组织肉瘤进行回顾性分析时，确定了8例在先前放射部位出现9例肉瘤的患者。八个满足辐射诱发肉瘤的标准。结果：辐射诱发的肉瘤发生在辐射后的10个月至50多年之间（中位数为7.35年）。诊断为肉瘤时，患者年龄范围为36至88岁（中位数为77.3岁）。从组织学上，诊断出4例恶性纤维组织细胞瘤，2例隆突性皮肤纤维肉瘤，2例癌肉瘤和1例纤维肉瘤。所有患者均接受手术作为主要治疗方法。在三种情况下无法实现完全切除。其中两人死于疾病。 5年疾病特异性生存率为50％，而5年总生存率为25％。结论：放疗可在数月至数年的潜伏期后诱发恶性肿瘤。放射线引起的肉瘤与总体预后不良有关。在大多数情况下，这种治疗是晚期且无效的。处于放射诱发的肉瘤发展风险中的人群正在增加，因此在这些患者的随访中需要保持警惕。

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