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首页> 外文期刊>The journal of pain: official journal of the American Pain Society >An overview of animal models of pain: Disease models and outcome measures
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An overview of animal models of pain: Disease models and outcome measures

机译：动物疼痛模型概述：疾病模型和结果指标

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摘要

Pain is ultimately a perceptual phenomenon. It is built from information gathered by specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and integrated into a discrete sensory experience with an emotional valence in the brain. Because of this, studying intact animals allows the multidimensional nature of pain to be examined. A number of animal models have been developed, reflecting observations that pain phenotypes are mediated by distinct mechanisms. Animal models of pain are designed to mimic distinct clinical diseases to better evaluate underlying mechanisms and potential treatments. Outcome measures are designed to measure multiple parts of the pain experience, including reflexive hyperalgesia measures, sensory and affective dimensions of pain, and impact of pain on function and quality of life. In this review, we discuss the common methods used for inducing each of the pain phenotypes related to clinical pain syndromes as well as the main behavioral tests for assessing pain in each model. Perspective Understanding animal models and outcome measures in animals will assist in translating data from basic science to the clinic.
机译：疼痛最终是一种知觉现象。它是由组织中专门的疼痛受体收集的信息构建而成的，并通过脊柱和棘上神经机制进行了修改，并整合到具有大脑情感价的离散感觉体验中。因此，研究完整的动物可以检查疼痛的多维性质。已经开发了许多动物模型，反映了观察到疼痛表型是由不同机制介导的观察结果。疼痛的动物模型旨在模仿不同的临床疾病，以更好地评估潜在的机制和潜在的治疗方法。成果措施旨在衡量疼痛经历的多个部分，包括反射性痛觉过敏措施，疼痛的感觉和情感范围以及疼痛对功能和生活质量的影响。在这篇综述中，我们讨论了用于诱发与临床疼痛综合征相关的每种疼痛表型的常用方法，以及评估每种模型中疼痛的主要行为测试。观点了解动物中的动物模型和结果测量将有助于将数据从基础科学转化为临床。

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