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Research Gaps in Practice Guidelines for Acute Postoperative Pain Management in Adults: Findings From a Review of the Evidence for an American Pain Society Clinical Practice Guideline

机译:成人急性术后疼痛管理实践指南中的研究空白:美国疼痛学会临床实践指南证据的审查结果

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摘要

Acute postoperative pain is a common clinical condition that, when poorly controlled, can result in a number of significant negative consequences. The American Pain Society commissioned an evidence-based guideline on the management of postoperative pain to promote evidence-based, safe, and effective perioperative pain management. An interdisciplinary panel developed 31 key questions and inclusion criteria to guide the evidence review. Investigators reviewed 6556 abstracts from multiple electronic databases up to November 2012, an updated evidence review to October 2014, and key references suggested by expert reviewers. More than 800 primary studies not included in a systematic review and 107 systematic reviews were included. Despite a large body of evidence, a number of critical research gaps were identified where only low-quality or insufficient evidence was found to help guide clinical practice recommendations. This report identifies evidence gaps including optimal methods and timing of perioperative patient education, nonpharmacological modalities, combinations of analgesic techniques, monitoring of patient response to treatment, techniques for neuraxial and regional analgesia, and organizational care delivery models. Recommendations to help guide the design of future perioperative studies are offered.
机译:急性术后疼痛是一种常见的临床症状,如果控制不佳,可能会导致许多重大的负面后果。美国疼痛学会委托有关术后疼痛管理的循证指南,以促进循证,安全和有效的围手术期疼痛管理。一个跨学科小组制定了31个关键问题和纳入标准,以指导证据审查。截至2012年11月,研究人员审查了来自多个电子数据库的6556个摘要,至2014年10月进行了最新的证据审查,并由专家审查者提出了关键参考。超过800项基础研究未纳入系统评价,其中包括107项系统评价。尽管有大量证据,但仍发现了许多关键的研究空白,其中仅发现质量低或证据不足以帮助指导临床实践建议。该报告指出了证据空白,包括围手术期患者教育的最佳方法和时机,非药理学方法,镇痛技术的组合,监测患者对治疗的反应,神经和局部镇痛技术以及组织护理提供模式。提供了有助于指导未来围手术期研究设计的建议。

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