...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Cloning genomic INGAP: a Reg-related family member with distinct transcriptional regulation sites
【24h】

Cloning genomic INGAP: a Reg-related family member with distinct transcriptional regulation sites

机译：克隆基因组INGAP：Reg相关的家族成员，具有独特的转录调控位点

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The protein product of hamster islet neogenesis-associated protein (INGAP) cDNA induces now pancreatic islet development. Manipulation of this process provides a new therapeutic strategy for the treatment of diabetes. As regulators of INGAP gene expression are unknown over 6 kb of hamster genomic INGAP has been cloned. Sequence analysis has identified a 3 kb 5-prime region with core promoter elements that is rich in transcription factor binding sites and six exons for the coding region. Analysis of promoter activity reveals stimulus-responsive DNA elements which have been identified though deletion analysis. Comparison of transcription factor binding sites in INGAP to the related gene RegIIIδ exposes potential sites for differential gene regulation.
机译：仓鼠胰岛新生相关蛋白（INGAP）cDNA的蛋白质产物现在诱导胰腺胰岛发育。对该过程的操纵为糖尿病的治疗提供了新的治疗策略。由于INGAP基因表达的调节剂未知，所以已经克隆了超过6kb的仓鼠基因组INGAP。序列分析已鉴定出具有核心启动子元件的3 kb 5-prime区，该启动子元件富含转录因子结合位点和六个外显子作为编码区。启动子活性的分析揭示了通过删除分析已鉴定出的刺激应答性DNA元件。 INGAP中转录因子结合位点与相关基因RegIIIδ的比较揭示了潜在的差异基因调控位点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号