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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Vitronectin in human breast carcinomas
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Vitronectin in human breast carcinomas

机译：玻璃体结合素在人类乳腺癌中的作用

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摘要

We have analysed the occurrence of the extracellular glycoprotein vitronectin in carcinomas and normal tissue of human breast. Immunohistochemical analysis of carcinomas revealed a strong vitronectin accumulation in extracellular matrix (ECM) around some cancer cell clusters and in the subendothelial area of some blood vessels. In normal tissue, Vitronectin had a homogeneous periductal occurrence, with local accumulation much lower than that in the carcinomas. Using a new solid phase radioligand assay, the vitronectin concentrations of extracts of carcinomas and normal breast tissue were determined and found to be indistinguishable. Comparison of the vitronectin and the hemoglobin concentrations of the extracts showed that their vitronectin content was not derived from blood contamination. Vitronectin mRNA was undetectable in both carcinomas and normal tissue. We conclude that vitronectin is not synthesised locally in breast tissue but derived by leakage from vessels, followed by extracellular accumulation in patterns distinctly different in carcinomas and normal tissue. The observation of a high vitronectin content in the carcinomas and its localization in the tissue contributes to the clarification of he role of vitronectin in tumour biology in interaction with the plasminogen activation system and integrins.
机译：我们已经分析了人乳癌和正常组织中细胞外糖蛋白玻连蛋白的发生。癌症的免疫组织化学分析显示，玻连蛋白在某些癌细胞簇周围和某些血管的内皮下区域中的细胞外基质（ECM）中有很强的玻连蛋白积累。在正常组织中，玻连蛋白在导管周围发生均质，局部积聚远低于癌组织。使用新的固相放射性配体测定法，确定了癌和正常乳腺组织提取物的玻连蛋白浓度，并且无法区分。提取物的玻连蛋白和血红蛋白浓度的比较表明，它们的玻连蛋白含量不是来源于血液污染。在癌和正常组织中均未检测到玻连蛋白mRNA。我们得出的结论是，玻连蛋白不是在乳腺组织中局部合成的，而是通过血管渗漏而产生的，随后细胞外积累的模式在癌组织和正常组织中明显不同。在癌中高玻连蛋白含量及其在组织中的定位的观察有助于澄清玻连蛋白与纤溶酶原激活系统和整联蛋白相互作用在肿瘤生物学中的作用。

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